Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders

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Flores López, María and García Marchena, Nuria and Araos, Pedro and Requena Ocaña, Nerea and Porras Perales, Oscar and Torres Galván, Sandra and Suarez, Juan and Pizarro, Nieves and Torre, Rafael de la and Rubio, Gabriel and Ruiz Ruiz, Juan Jesús and Rodríguez de Fonseca, Fernando and Serrano, Antonia and Pavón Morón, Francisco Javier (2022) Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders. Brain Sciences, 12 (5). p. 588. ISSN 2076-3425

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Official URL: https://doi.org/10.3390/brainsci12050588




Abstract

Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.


Item Type:Article
Uncontrolled Keywords:lysophosphatidic acid; biomarker; sex; substance use disorder; alcohol; cocaine
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Psychology > Drug abuse
ID Code:72847
Deposited On:27 Jun 2022 13:46
Last Modified:28 Jun 2022 10:50

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