A Prospective Study of the Serological, Clinical, and Epidemiological Features of a SARS-CoV-2 Positive Pediatric Cohort

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Callejas Caballero, Ignacio and Ruedas López, Alba and Berzosa Sánchez, Arantxa and Illán Ramos, Marta and Joyanes Abancens, Belén and Bodas Pinedo, Andrés and Guillén Martín, Sara and Soto Sánchez, Beatriz and García Bermejo, Isabel and Molina Arana, David and Alós, Juan-Ignacio and Baos Muñoz, Elvira and Delgado Iribarren, Alberto and Fuentes Ferrer, Manuel E. and Ramos Amador, José Tomás (2022) A Prospective Study of the Serological, Clinical, and Epidemiological Features of a SARS-CoV-2 Positive Pediatric Cohort. Children, 9 (5). p. 665. ISSN 2227-9067

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Official URL: https://doi.org/10.3390/children9050665




Abstract

Background: SARS-CoV-2 was a global pandemic. Children develop a mild disease and may have a different rate of seroconversion compared to adults. The objective was to determine the number of seronegative patients in a pediatric cohort. We also reviewed the clinical–epidemiological features associated with seroconversion. Methods: A multicenter prospective observational study during September–November 2020, of COVID-19, confirmed by reverse transcription-polymerase chain reaction. Data were obtained 4–8 weeks after diagnosis. Blood samples were collected to investigate the humoral response, using three different serological methods. Results: A total of 111 patients were included (98 symptomatic), 8 were admitted to hospital, none required an Intensive Care Unit visit. Median age: 88 months (IQR: 24–149). Median time between diagnosis and serological test: 37 days (IQR: 34–44). A total of 19 patients were non-seroconverters when using three serological techniques (17.1%; 95% CI: 10.6–25.4); most were aged 2–10 years (35%, p < 0.05). Univariate analysis yielded a lower rate of seroconversion when COVID-19 confirmation was not present amongst household contacts (51.7%; p < 0.05). Conclusions: There was a high proportion of non-seroconverters. This is more commonly encountered in childhood than in adults. Most seronegative patients were in the group aged 2–10 years, and when COVID-19 was not documented in household contacts. Most developed a mild disease. Frequently, children were not the index case within the family.


Item Type:Article
Uncontrolled Keywords:RT-PCR (reverse transcriptase polymerase chain reaction); SARS-CoV-2; COVID-19; seroconversion; children
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Medicine > Pediatrics
ID Code:72853
Deposited On:17 Jun 2022 16:05
Last Modified:27 Jun 2022 08:38

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