Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose

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Zekri Nechar, Khaoula and Zamorano León, José J. and Segura Fragoso, Antonio and Alcaide, José R. and Reche, Carmen and Andrés Castillo, Alcira and Martínez Martínez, Carlos H. and Giner, Manel and Jiménez García, Rodrigo and López de Andrés, Ana and Navarro Cuéllar, Carlos and García Fernández, Miguel A. and López Farré, Antonio José (2022) Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose. Journal of Clinical Medicine, 11 (3). p. 587. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm11030587




Abstract

(1) Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability.
(2) Methods: A multicenter retrospective cohort of 1555 COVID-19-infected adult patients from public hospitals of the Madrid community were analyzed.
(3) Results: Logistic regression analysis showed increased mortality for ages higher than 49 y. After adjusting for age, comorbidities and on-admission glucose levels, it was found that on-admission serum albumin ≥3.5 g/dL was significantly associated with reduced mortality (OR 0.48; 95%CI:0.36–0.62). There was an inverse concentration-dependent association between on-admission albumin levels and <30 days in-hospital all-cause mortality. However, when on-admission glucose levels were above 125 mg/dL, higher levels of serum albumin were needed to reach an association with survival. In vitro experiments showed that the spike protein S1 subunit of SARS-CoV-2 binds to native albumin. The binding ability of native albumin to the spike protein S1 subunit was decreased in the presence of an increasing concentration of glycated albumin.
(4) Conclusions: On-admission serum albumin levels were inversely associated with <30 days in-hospital all-cause mortality. Native albumin binds the spike protein S1 subunit, suggesting that native albumin may act as a scavenger of the SARS-CoV-2 virus.


Item Type:Article
Uncontrolled Keywords:albumin; COVID-19; glucose; glycated albumin; in-hospital mortality; spike protein S1 subunit
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Medicine > Immunology
ID Code:72861
Deposited On:16 Jun 2022 14:28
Last Modified:17 Jun 2022 07:15

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