Impact of Negative Symptoms on Functioning and Quality of Life in First Psychotic Episodes of Schizophrenia



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García Fernández, Lorena and Romero Ferreiro, Verónica and Sánchez Pastor, Luis and Dompablo, Mónica and Martínez Gras, Isabel and Espejo Saavedra, Juan Manuel and Rentero, David and Aparicio, Ana Isabel and Alvarez Mon, Miguel Ángel and Lahera, Guillermo and Lee, Jimmy and Santos, Jose Luis and Rodríguez Jiménez, Roberto (2022) Impact of Negative Symptoms on Functioning and Quality of Life in First Psychotic Episodes of Schizophrenia. Journal of Clinical Medicine, 11 (4). p. 983. ISSN 2077-0383

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Negative symptoms are not considered a unitary construct encompassing two different domains, diminished expression, and avolition-apathy. The aim of this study was to explore the relationships between each domain and psychosocial functioning and quality of life in people with a first psychotic episode of schizophrenia. In total, 61 outpatients were assessed with the Clinical Assessment Interview for Negative Symptoms (CAINS), The Functioning Assesment Short Test (FAST) and The Quality of Life Scale (QLS). The mean global score for CAINS was 21.5 (SD: 15.6), with a CAINS Avolition-Apathy (MAP) score of 17.0 (SD: 11.8), and CAINS Diminished Expression (EXP) score of 4.5 (SD: 5.0). The mean FAST score was 31.9 (SD: 18.9), and 41.1 (SD: 17.9) for QLS. Linear regression analysis revealed a significant (F(4,53) = 15.65, p < 0.001) relationship between MAP and EXP CAINS’ score and FAST score. CAINS-MAP was more predictive of FAST scores (β = 0.44, p = 0.001) than CAINS-EXP (β = 0.37, p = 0.007). Linear regression analysis for QLS revealed a significant model (F(4,56) = 29.29, p < 0.001). The standardized regression weight for the CAINS-MAP was around three times greater (β = −0.63, p < 0.001) than for CAINS-EXP (β = −0.24, p = 0.024). The two different domains are associated differently with functionality and quality of life.

Item Type:Article
Uncontrolled Keywords:negative symptoms; expressive deficits; experiential deficits; functioning; quality of life; first psychotic episode
Subjects:Medical sciences > Medicine > Psychiatry
ID Code:72863
Deposited On:15 Jun 2022 13:42
Last Modified:16 Jun 2022 07:09

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