The Influence of Atrial Fibrillation on In-Hospital Mortality in People with Hospital-Acquired Pneumonia: An Observational, Sex-Stratified Study

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Miguel Yanes, José María de and Jiménez García, Rodrigo and Miguel Díez, Javier de and Hernández Barrera, Valentín and Méndez Bailón, Manuel and Zamorano León, José J. and López de Andrés, Ana (2022) The Influence of Atrial Fibrillation on In-Hospital Mortality in People with Hospital-Acquired Pneumonia: An Observational, Sex-Stratified Study. Journal of Clinical Medicine, 11 (5). p. 1179. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm11051179




Abstract

(1) Background: The study aimed to analyze the influence of atrial fibrillation (AF) prior to hospital admission (“prevalent”) and new-onset AF diagnosed during hospital admission (“incident”) on in-hospital mortality (IHM) in women and men who developed hospital-acquired pneumonia (HAP) in Spain (2016–2019).
(2) Methods: We used the Spanish Register of Specialized Care-Basic Minimum Database.
(3) Results: We analyzed 38,814 cases of HAP (34.6% women; 13.5% ventilator-associated). Prevalent AF was coded in 19.9% (n = 7742), and incident AF in 5.5% (n = 2136) of HAP. Crude IHM was significantly higher for prevalent AF (34.22% vs. 27.35%, p < 0.001) and for incident AF (35.81% vs. 28.31%, p < 0.001) compared to no AF. After propensity score matching, IHM among women and men with prevalent AF was higher than among women and men with no AF (among women, 32.89% vs. 30.11%, p = 0.021; among men, 35.05% vs. 32.46%, p = 0.008). Similarly, IHM among women and men with incident AF was higher than among women and men with no AF (among women, 36.23% vs. 29.90%, p = 0.013; among men, 35.62% vs. 30.47%; p = 0.003). Sex was associated with a higher IHM only in people with incident AF (for female, OR = 1.21; 95% CI: 1.01–1.57).
(4) Conclusions: Both prevalent and incident AF were associated with higher IHM in people who developed HAP. Female sex was associated with a higher IHM in incident AF.


Item Type:Article
Uncontrolled Keywords:atrial fibrillation; hospital-acquired pneumonia; sex differences; in-hospital mortality
Subjects:Medical sciences > Medicine > Pneumology
ID Code:72866
Deposited On:15 Jun 2022 13:27
Last Modified:16 Jun 2022 07:15

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