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Prognostic Significance of the PROFUND Index on One Year Mortality in Acute Heart Failure: Results from the RICA Registry



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Méndez Bailón, Manuel and Iguarán Bermúdez, Rosario and Formiga Pérez, Francesc and Arévalo Lorido, José Carlos and Suárez Pedreira, Iván and Morales Rull, Jose Luis and Serrado Iglesias, Ana and Llacer Iborra, Pau and Ormaechea Gorricho, Gabriela and Carrasco Sánchez, Francisco Javier and Casado Cerrada, Jesús and Andrès, Emmanuel and Diez Manglano, Jesús and Lorenzo Villalba, Noel and Montero Pérez Barquero, Manuel (2022) Prognostic Significance of the PROFUND Index on One Year Mortality in Acute Heart Failure: Results from the RICA Registry. Journal of Clinical Medicine, 11 (7). p. 1876. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm11071876


Background: Heart failure (HF) is a syndrome with high prevalence, mainly affecting elderly patients, where the presence of associated comorbidities is of great importance. Methods: An observational study from a prospective registry was conducted. Patients identified from the National Registry of Heart Failure (RICA), which belongs to the Working Group on Heart Failure and Atrial Fibrillation of the Spanish Society of Internal Medicine (SEMI), were included. The latter is a prospective, multicenter registry that has been active since 2008. It includes individual consecutive patients over 50 years of age with a diagnosis of HF at hospital discharge (acute decompensated or new-onset HF). Results: In total, 5424 patients were identified from the registry. Forty-seven percent were men and mean left ventricular ejection fraction (LVEF) was 51.4%; 1132 had a score of 0 to 2 according to the PROFUND index, 3087 had a score of 3 to 6, and 952 patients had a score of 7 to 10 points. In the sample, 252 patients had a score above 11 points. At the end of the year of follow-up, 61% of the patients died. This mortality increased proportionally as the PROFUND index increased, specifically 75% for patients with PROFUND greater than 11. The Kaplan-Meier survival curve shows that survival at one year progressively decreases as the PROFUND index value increases. Thus, subjects with scores greater than seven (intermediate-high and high-risk) presented the worst survival with a log rank of 0.96 and a p < 0.05. In the regression analysis, we found a higher risk of death from any cause at one year in the group with the highest risk according to the PROFUND index (score greater than 11 points (HR 1.838 (1.410–2.396)). Conclusions: The PROFUND index is a good index for predicting mortality in patients admitted for acute HF, especially in those subjects at intermediate to high risk with scores above seven. Future studies should seek to determine whether the PROFUND index score is simply a prognostic marker or whether it can also be used to make therapeutic decisions for those subjects with very high short-term mortality.

Item Type:Article
Uncontrolled Keywords:heart failure; comorbidities; PROFUND index
Subjects:Medical sciences > Medicine > Cardiology
ID Code:72871
Deposited On:14 Jun 2022 13:52
Last Modified:15 Jun 2022 07:08

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