Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients

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Fuso, Paola and Di Salvatore, Mariantonietta and Santonocito, Concetta and Guarino, Donatella and Autilio, Chiara and Mulè, Antonino and Arciuolo, Damiano and Rinninella, Antonina and Mignone, Flavio and Ramundo, Matteo and Di Stefano, Brunella and Orlandi, Armando and Capoluongo, Ettore and Nicolotti, Nicola and Franceschini, Gianluca and Martín Sánchez, Alejandro and Tortora, Giampaolo and Scambia, Giovanni and Barone, Carlo and Cassano, Alessandra (2021) Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients. Journal of Personalized Medicine, 11 (8). p. 816. ISSN 2075-4426

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Official URL: https://doi.org/10.3390/jpm11080816




Abstract

Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC).
Patients and methods: We retrospectively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next-Generation-Sequencing (NGS) system.
Results: Event-free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let-7a-5p (EFS p = 0.006; OS p = 0.0001), mirR-100-5p (EFS s p = 0.01; OS p = 0.03), miR-101-3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let-7a-5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up-regulation of the above miRNAs could represent biomarkers in breast cancer.


Item Type:Article
Uncontrolled Keywords:subtypes breast cancer; miRNAs; breast cancer treatment; chemotherapy; integrated therapies; next-generation-sequencing; target therapy; precision medicine; personalized medicine
Subjects:Medical sciences > Medicine > Oncology
ID Code:72872
Deposited On:14 Jun 2022 13:48
Last Modified:15 Jun 2022 07:13

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