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Understanding brain function in vascular cognitive impairment and dementia with EEG and MEG: A systematic review



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Torres Simón, Lucía and Doval Moreno, Sandra and Nebreda Pérez, Alberto and Llinas, Sophia J. and Marsh, Elisabeth B. and Maestú Unturbe, Fernando (2022) Understanding brain function in vascular cognitive impairment and dementia with EEG and MEG: A systematic review. Neuroimage: clinical, 35 . ISSN 2213-1582

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Official URL: https://doi.org/10.1016/j.nicl.2022.103040


Vascular Cognitive Impairment (VCI) is the second most prevalent dementia after Alzheimer’s Disease (AD), and cerebrovascular disease (CBVD) is a major comorbid contributor to the progression of most neurodegenerative diseases. Early differentiation of cognitive impairment is critical given both the high prevalence of CBVD, and that its risk factors are modifiable. The ability for electroencephalogram (EEG) and magnetoencephalogram (MEG) to detect changes in brain functioning for other dementias suggests that they may also be promising biomarkers for early VCI. The present systematic review aims to summarize the literature regarding electrophysiological patterns of mild and major VCI. Despite considerable heterogeneity in clinical definition and electrophysiological methodology, common patterns exist when comparing patients with VCI to healthy controls (HC) and patients with AD, though there is a low specificity when comparing between VCI subgroups. Similar to other dementias, slowed frequency patterns and disrupted inter- and intra-hemispheric connectivity are repeatedly reported for VCI patients, as well as longer latencies and smaller amplitudes in evoked responses. Further study is needed to fully establish MEG and EEG as clinically useful biomarkers, including a clear definition of VCI and standardized methodology, allowing for comparison across groups and consolidation of multicenter efforts.

Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:Vascular Cognitive Impairment (VCI) ; Vascular Dementia (VaD) ; Neurophysiology ; Electroencephalogram; Magnetoencephalogram
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Psychology > Neuropsychology
ID Code:72905
Deposited On:16 Jun 2022 10:48
Last Modified:03 Feb 2023 14:02

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