Endothelial senescence and the chronic vascular diseases: challenges and therapeutic opportunities in atherosclerosis



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Ramírez, Rafael and Ceprián Costoso, Noemí and Figuer, Andrea and Valera Arévalo, Gemma and Bodega, Guillermo and Alique, Matilde and Carracedo Añón, Julia María (2022) Endothelial senescence and the chronic vascular diseases: challenges and therapeutic opportunities in atherosclerosis. Journal of Personalized Medicine, 12 (2). pp. 1-11. ISSN Electronic: 2075-4426

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Official URL: https://doi.org/10.3390/jpm12020215


Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation. These factors are increased in the elderly and from chronic disease patients. Elevated levels of oxidative stress affect cellular function and metabolism, inducing senescence. This senescence modifies the cell phenotype into a senescent secretory phenotype. This phenotype activates immune cells, leading to chronic systemic inflammation. Moreover, due to their secretory phenotype, senescence cells present an increased release of highlighted extracellular vesicles that will change nearby/neighborhood cells and paracrine signaling. For this reason, searching for specific senescent cell biomarkers and therapies against the development/killing of senescent cells has become relevant. Recently, senomorphic and senolityc drugs have become relevant in slowing down or eliminating senescence cells. However, even though they have shown promising results in experimental studies, their clinical use is still yet to be determined.

Item Type:Article
Uncontrolled Keywords:Atherosclerosis; Cellular senescence; Endothelial senescence; Extracellular vesicles; Inflammation; Senolityc
Subjects:Medical sciences > Medicine > Physiology
Medical sciences > Medicine > Cardiovascular system
ID Code:73020
Deposited On:21 Jun 2022 11:58
Last Modified:27 Jun 2022 10:03

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