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Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors



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López Cuenca, Inés and García Martín, Elena Salobrar and Sánchez Puebla, Lídia and Espejel Checa, Eva and García del Arco, Lucía and Rojas Lozano, Pilar and Elvira Hurtado, Lorena and Fernández Albarral, José Antonio and Ramírez Toraño, Federico and Barabash, Ana and Salazar Corral, Juan José and Ramirez Sebastian, Jose Manuel and Hoz Montañana, María Rosa de and Ramírez Sebastián, Ana Isabel (2022) Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors. Journal of Clinical Medicine, 11 (11). 18 p.. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm11113248


In 103 subjects with a high genetic risk of developing Alzheimer’s disease (AD), family history (FH) of AD and ApoE ɛ4 characterization (ApoE ɛ4) were analyzed for changes in the retinal vascular network by OCTA (optical coherence tomography angiography), and AngioTool and Erlangen-Angio-Tool (EA-Tool) as imaging analysis software. Retinal vascularization was analyzed by measuring hypercholesterolemia (HCL) and high blood pressure (HBP). Angio-Tool showed a statistically significant higher percentage of area occupied by vessels in the FH+ ApoE ɛ4- group vs. in the FH+ ApoE ɛ4+ group, and EA-Tool showed statistically significant higher vascular densities in the C3 ring in the FH+ ApoE ɛ4+ group when compared with: i)FH- ApoE ɛ4- in sectors H3, H4, H10 and H11; and ii) FH+ ApoE ɛ4- in sectors H4 and H12. In participants with HCL and HBP, statistically significant changes were found, in particular using EA-Tool, both in the macular area, mainly in the deep plexus, and in the peripapillary area. In conclusion, OCTA in subjects with genetic risk factors for the development of AD showed an apparent increase in vascular density in some sectors of the retina, which was one of the first vascular changes detectable. These changes constitute a promising biomarker for monitoring the progression of pathological neuronal degeneration.

Item Type:Article
Additional Information:

This article belongs to the Special Issue Predicting the Evolution of Neurological Diseases: The Role of Biomarkers in 2022 and Beyond

Uncontrolled Keywords:Alzheimer’s disease; genetic risk; ApoE ɛ4; familiar history; OCTA; AngioTool; EA-Tool; retina; vascular density; cardiovascular risk factors; hypercholesterolemia; high blood pressure
Subjects:Medical sciences > Medicine > Medical genetics
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:73141
Deposited On:27 Jun 2022 12:21
Last Modified:28 Jun 2022 10:38

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