Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis

Impacto

Downloads

Downloads per month over past year

López Cuenca, Inés and García Martín, Elena Salobrar and Gil Salgado, Inés and Sánchez Puebla, Lídia and Elvira Hurtado, Lorena and Fernández Albarral, José Antonio and Ramírez Toraño, Federico and Barabash, Ana and Frutos Lucas, Jaisalmer de and Salazar Corral, Juan José and Ramirez Sebastian, Jose Manuel and Ramírez Sebastián, Ana Isabel and Hoz Montañana, María Rosa de (2022) Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis. Journal of Personalized Medicine, 12 (5). 15 p.. ISSN 2075-4426

[thumbnail of 2022  Journal Personalized Medicine 12 (00847) - Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimes Disease.pdf] PDF
Creative Commons Attribution.

1MB

Official URL: https://doi.org/10.3390/jpm12050847




Abstract

Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH- or FH+) and their allelic characterization of ApoE ɛ4 (ApoE ɛ4- or ApoE ɛ4+) and considering cardiovascular risk factors (hypercholesterolemia, hypertension, and diabetes mellitus). In addition, we analyzed the choroidal thickness by OCT and the area of the foveal avascular zone with OCTA. We did not find a relationship between a family history of AD or any of the ApoE isoforms and the presence or absence of drusen. Subjects with drusen show choroidal thinning compared to patients without drusen, and thinning could trigger changes in choroidal perfusion that may give rise to the deposits that generate drusen


Item Type:Article
Additional Information:

Received: 19 April 2022 / Revised: 17 May 2022 / Accepted: 19 May 2022 / Published: 23 May 2022

Uncontrolled Keywords:Alzheimer’s disease; ApoE ɛ4; family history; hard drusen; OCT; retina; AMD; hypercholesterolemia; hypertension; diabetes mellitus; choroid
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:73146
Deposited On:28 Jun 2022 10:41
Last Modified:28 Jun 2022 11:49

Origin of downloads

Repository Staff Only: item control page