Electrophysiological resting‐state hyperconnectivity and poorer behavioural regulation as predisposing profiles of adolescent binge drinking



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Antón Toro, Luis F. and Bruña Fernández, Ricardo and Cerro León, Alberto del and Shpakivska Bilan, Danylyna and Mateos Gordo, Patricia and Porras Truque, Claudia Marcela and García Gómez, Raquel and Maestú Unturbe, Fernando and García Moreno, Luis Miguel (2022) Electrophysiological resting‐state hyperconnectivity and poorer behavioural regulation as predisposing profiles of adolescent binge drinking. Addiction Biology, 27 (4). ISSN 1355-6215

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Official URL: https://doi.org/10.1111/adb.13199


Adolescent Binge Drinking (BD) has become an increasing health and social concern, with detrimental consequences for brain development and functional integrity. However, research on neurophysiological and neuropsychological traits predisposing to BD are limited at this time. In this work, we conducted a 2-year longitudinal magnetoencephalography (MEG) study over a cohort of initially alcohol-naïve adolescents with the purpose of exploring anomalies in resting-state electrophysiological networks, impulsivity, sensation-seeking, and dysexecutive behaviour able to predict future BD patterns. In a sample of 67 alcohol-naïve adolescents (age = 14.5 ± 0.9), we measured resting-state activity using MEG. Additionally, we evaluated their neuropsychological traits using self-report ecological scales (BIS-11, SSS-V, BDEFS, BRIEF-SR and DEX). In a second evaluation, 2 years later, we measured participant's alcohol consumption, sub-dividing the original sample in two groups: future binge drinkers (22 individuals, age 14.6 ± 0.8; eight females) and future light/no drinkers (17 individuals, age 14.5 ± 0.8; eight females). Then, we searched for differences predating alcohol BD intake. We found abnormalities in MEG resting state, in a form of gamma band hyperconnectivity, in those adolescents who transitioned into BD years later. Furthermore, they showed higher impulsivity, dysexecutive behaviours and sensation seeking, positively correlated with functional connectivity (FC). Sensation seeking and impulsivity mainly predicted BD severity in the future, while the relationship between dysexecutive trait and FC with future BD was mediated by sensation seeking. These findings shed light to electrophysiological and neuropsychological traits of vulnerability towards alcohol consumption. We hypothesise that these differences may rely on divergent neurobiological development of inhibitory neurotransmission pathways and executive prefrontal circuits.

Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:binge drinking, executive functions, functional connectivity, magnetoencephalography, resting state, sensation seeking
Subjects:Medical sciences > Psychology > Neuropsychology
Medical sciences > Psychology > Experimental psychology
ID Code:73267
Deposited On:30 Jun 2022 08:51
Last Modified:04 Aug 2022 11:03

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