Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences



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Biezma, María and Muñoz, Patricia and Villa, Sofía de la and Fariñas Álvarez, María and Arnáiz de las Revillas, Francisco and Gutiérrez Carretero, Encarnación and Alarcón, Arístides de and Rodríguez García, Raquel and Llopis, Jaume and Goenaga, Miguel and Gutiérrez Villanueva, Andrea and Plata, Antonio and Vidal, Laura and Martínez Sellés d'Oliveira Soares, Manuel (2022) Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences. Journal of Clinical Medicine, 11 (9). p. 2651. ISSN 2077-0383

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Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.

Item Type:Article
Uncontrolled Keywords:infective endocarditis; diabetes mellitus; prognosis; in-hospital mortality; one-year mortality; organ damage
Subjects:Medical sciences > Medicine > Endocrinology
ID Code:73351
Deposited On:14 Jul 2022 14:45
Last Modified:02 Aug 2022 10:29

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