The Integration of Cell Therapy and Biomaterials as Treatment Strategies for Remyelination

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López Muguruza, Eneritz and Villar Gómez, Natalia and Matías-Guiu Guia, Jordi A. and Selma Calvo, Belen and Moreno Jiménez, Lidia and Sancho Bielsa, Francisco and Lopez Carbonero, Juan and Benito Martín, María Soledad and García Flores, Silvia and Bonel García, Natalia and Kamal, Ola Mohamed Fathy and Ojeda Hernández, Denise and Matias Guiu, Jorge and Gómez Pinedo, Ulises (2022) The Integration of Cell Therapy and Biomaterials as Treatment Strategies for Remyelination. Life, 12 (4). p. 474. ISSN 2075-1729

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Official URL: https://doi.org/10.3390/life12040474




Abstract

Multiple sclerosis (MS) is a chronic degenerative autoimmune disease of the central nervous system that causes inflammation, demyelinating lesions, and axonal damage and is associated with a high rate of early-onset disability. Disease-modifying therapies are used to mitigate the inflammatory process in MS but do not promote regeneration or remyelination; cell therapy may play an important role in these processes, modulating inflammation and promoting the repopulation of oligodendrocytes, which are responsible for myelin repair. The development of genetic engineering has led to the emergence of stable, biocompatible biomaterials that may promote a favorable environment for exogenous cells. This review summarizes the available evidence about the effects of transplantation of different types of stem cells reported in studies with several animal models of MS and clinical trials in human patients. We also address the advantages of combining cell therapy with biomaterials.


Item Type:Article
Uncontrolled Keywords:Multiple sclerosis; remyelination; cell therapy; biomaterials
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Biology > Cytology
ID Code:73362
Deposited On:07 Jul 2022 16:03
Last Modified:08 Jul 2022 07:23

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