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Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study



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Escobedo Aedo, Paula Jhoana and Forjan González, Ana and Sánchez Escribano Martínez, Adela and Ruiz Ruano, Verónica González and Sánchez Alonso, Sergio and Mata Iturralde, Laura and Muñoz Lorenzo, Laura and Baca García, Enrique and David, Anthony S. and Lopez Morinigo, Javier-David (2022) Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study. Behavioral Sciences, 12 (2). p. 28. ISSN 2076-328X

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Official URL: https://doi.org/10.3390/bs12020028


Background: Recovery has become a priority in schizophrenia spectrum disorders (SSDs). This study aimed to investigate predictors of objective—general functioning and disability—and subjective—quality of life (QoL)—measures of functional outcomes in SSD.

Methods: Sample: n = 77 SSD outpatients (age 18–64, IQ > 70) participating in a randomised controlled trial. Baseline data were used to build three multivariable linear regression models on: (i) general functioning—General Assessment of Functioning (GAF); (ii) disability—the World Health Organization Disability Assessment Schedule (WHODAS-2.0); and (iii) QoL—Satisfaction Life Domains Scale (SLDS).

Results: Young age and being employed (R2 change = 0.211; p = 0.001), late adolescence premorbid adjustment (R2 change = 0.049; p = 0.0050), negative symptoms and disorganization (R2 change = 0.087; p = 0.025) and Theory of Mind (R2 change = 0.066, p = 0.053) predicted general functioning. Previous suicidal behaviour (R2 change = 0.068; p = 0.023) and negative and depressive symptoms (R2 change = 0.167; p = 0.001) were linked with disability. Previous suicidal behaviour (R2 change = 0.070, p = 0.026), depressive symptoms (R2 change = 0.157; p < 0.001) and illness recognition (R2 change = 0.046, p = 0.044) predicted QoL.

Conclusions: Negative, disorganization and depressive symptoms, older age, unemployment, poor premorbid adjustment, previous suicide attempts and illness awareness appear to underlie a poor global functional outcome in SSD. Achieving recovery in SSD appears to require both symptomatic remission (e.g., through antipsychotics) and measures to improve mastery and relieve low mood.

Item Type:Article
Uncontrolled Keywords:metacognition; schizophrenia spectrum disorders; disability; functioning; quality of life
Subjects:Medical sciences > Medicine > Psychiatry
ID Code:73376
Deposited On:05 Jul 2022 13:39
Last Modified:06 Jul 2022 07:34

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