Morphine with or without Acepromazine in Horses: A Kinematic Evaluation

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López Sanromán, Francisco Javier and Montes Freilich, Gloria and Gómez Cisneros, David and Izquierdo Moreno, José and Varela del Arco, María and Manso Díaz, Gabriel (2022) Morphine with or without Acepromazine in Horses: A Kinematic Evaluation. Animals, 12 (9). p. 1193. ISSN 2076-2615

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Official URL: https://doi.org/10.3390/ani12091193




Abstract

Morphine is an opioid agonist drug and produces a significant analgesic effect in horses but besides the evidenced analgesic effect, the use of morphine is not routine due to the potential excitatory effects described in the literature. To minimize these effects, neuroleptanalgesia, or the combination of opioids and sedative drugs, is encouraged. Our aim was to describe changes occurring in the locomotor pattern after co-administration of a tranquilizer, acepromazine, and morphine in horses. Six mature horses were used and received four different treatments with saline solution, morphine, acepromazine, or a combination of morphine and acepromazine. A three-dimensional accelerometric device was used to collect data and objectivize those findings moreover the sedative effect of the treatments was also measured. Significant differences were observed when comparing all the treatments in the majority of accelerometric variables, except the regularity of the pattern, some energetic parameters, and tranquilization. An evident counteraction of the effects caused by both morphine and acepromazine was observed. Due to these effects, the possibility of adding acepromazine to an additional analgesic treatment with morphine in the clinical setting ensures the absence of the supplemental instability caused by other sedatives and minimizes the potential opioid excitatory effects.


Item Type:Article
Uncontrolled Keywords:gait analysis; accelerometry; acepromazine; morphine; horse
Subjects:Medical sciences > Veterinary > Veterinary clinics and hospitals
Medical sciences > Veterinary > Equidae
ID Code:73380
Deposited On:04 Jul 2022 14:22
Last Modified:05 Jul 2022 08:22

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