Diversity of Hemodynamic Reactive Profiles across Persons—Psychosocial Implications for Personalized Medicine
Diversidad de perfiles reactivos hemodinámicos entre personas. Implicaciones psicosociales para una medicina personalizada.



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Gandarillas Solinís, Miguel Ángel and Goswami, Nandu (2022) Diversity of Hemodynamic Reactive Profiles across Persons—Psychosocial Implications for Personalized Medicine. Journal of Clinical Medicine, 11 . p. 3869. ISSN 2077-0383

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This study analyzed the individual differences in hemodynamic time patterns and reactivity to cognitive and emotional tasks, and explored the diversity of psycho-physiological profiles that could be used for the personalized prediction of different diseases. An analysis of heart rate (HR)—blood pressure (BP) relationship patterns across time using cross-correlations (CCs) during a logical-mathematical task and a task recalling negative emotions (rumination) was carried out in a laboratory setting on 45 participants. The results showed maximum HR–BP CCs during the mathematical task significantly more positive than the maximum HR–BP CCs during the rumina-tion task. Furthermore, our results showed a large variety of hemodynamic reactivity profiles across the participants, even when carrying out the same tasks. The most frequent type showed positive HR–BP CCs under cognitive activity, and several positive–negative HR–BP CCs cycles under negative emotional activity. In general terms, our results supported the main hypothesis. We observed some distinct time-based “coordination strategies” in the reactivity of the autonomic nervous system under emotional vs. cognitive loading. Overall, large individual, as well as situa-tional, specificities in hemodynamic reactivity time patterns were seen. The possible relationships between this variety of profiles and different psychosocial characteristics, and the potential for in-tegrative predictive health within the provision of highly personalized medicine, are discussed.

Item Type:Article
Uncontrolled Keywords:autonomic nervous system; hemodynamics; predictive health; personalized medicine; psychosocial factors; integrative medicine
Subjects:Medical sciences > Medicine > Physiology
Medical sciences > Medicine > Cardiovascular system
Medical sciences > Psychology > Social psychology
ID Code:73431
Deposited On:06 Jul 2022 06:39
Last Modified:06 Jul 2022 06:39

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