The Role of Propranolol as a Repurposed Drug in Rare Vascular Diseases

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Cuesta Martínez, Ángel and Gallardo Vara, Eunate María and Casado Vela, Juan and Recio Poveda, Lucía and Botella, Luisa María and Albiñana, Virginia (2022) The Role of Propranolol as a Repurposed Drug in Rare Vascular Diseases. International Journal of Molecular Sciences, 23 (8). p. 4217. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms23084217




Abstract

Rare Diseases (RD) are defined by their prevalence in less than 5 in 10,000 of the general population. Considered individually, each RD may seem insignificant, but together they add up to more than 7000 different diseases. Research in RD is not attractive for pharmaceutical companies since it is unlikely to recover development costs for medicines aimed to small numbers of patients. Since most of these diseases are life threatening, this fact underscores the urgent need for treatments. Drug repurposing consists of identifying new uses for approved drugs outside the scope of the original medical indication. It is an alternative option in drug development and represents a viable and risk-managed strategy to develop for RDs. In 2008, the “off label” therapeutic benefits of propranolol were described in the benign tumor Infantile Hemangioma. Propranolol, initially prescribed for high blood pressure, irregular heart rate, essential tremor, and anxiety, has, in the last decade, shown increasing evidence of its antiangiogenic, pro-apoptotic, vasoconstrictor and anti-inflammatory properties in different RDs, including vascular or oncological pathologies. This review highlights the finished and ongoing trials in which propranolol has arisen as a good repurposing drug for improving the health condition in RDs.


Item Type:Article
Uncontrolled Keywords:beta-adrenergic receptor antagonist; propranolol; HIF; apoptosis; inflammation; angiogenesis
Subjects:Medical sciences > Medicine > Cardiology
Medical sciences > Medicine > Cardiovascular system
Medical sciences > Biology > Molecular biology
ID Code:73901
Deposited On:21 Jul 2022 13:21
Last Modified:03 Aug 2022 08:44

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