Phenolic Acids and Flavonoids in Acetonic Extract from Quince (Cydonia oblonga Mill.): Nutraceuticals with Antioxidant and Anti-Inflammatory Potential

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Herrera Rocha, Karen Marlenne and Rocha Guzmán, Nuria Elizabeth and Gallegos Infante, José Alberto and González Laredo, Rubén Francisco and Larrosa Pérez, María del Mar and Moreno Jiménez, Martha Rocío (2022) Phenolic Acids and Flavonoids in Acetonic Extract from Quince (Cydonia oblonga Mill.): Nutraceuticals with Antioxidant and Anti-Inflammatory Potential. Molecules, 27 (8). p. 2462. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules27082462




Abstract

Quince (Cydonia oblonga Mill.) is a potential source of polyphenolic compounds related with beneficial biological processes. In this study polyphenols from quince fruit were extracted with aqueous acetone at different ratios. A polyphenol profile was identified and quantified by LC-ESI-QqQ. The antioxidant capacity (ORAC and DPPH) and anti-inflammatory effect (inhibition of COX-2 cyclooxygenase) were evaluated in vitro. The results indicated an effect of the aqueous acetone ratio on the extraction of polyphenolic compounds. The higher extraction yields of polyphenolic compounds were attained with 60–75% aqueous acetone. However, extracts obtained with 85% aqueous acetone promoted higher antioxidant and anti-inflammatory effects. Optimal scaling analysis indicated that hydroxycinnamic acids (quinic and chlorogenic), hydroxybenzoic acids (vanillic and syringic), flavonoids (quercetin and kaempferol), dihydrochalcones (neohesperidin) and flavones (acacetin) are related to the antioxidant activity of quince. While phenolic acids, flavonols (kaempferol-3-O-glucoside and rutin) and flavanols (epicatechin) generated the anti-inflammatory effect by inhibiting 52.3% of the COX-2 enzyme. Therefore, a selective extraction of phenolic mix can reduce oxidative stress or inflammatory processes. This suggests the use of quince as a natural source with significant nutraceutical potential.


Item Type:Article
Uncontrolled Keywords:quince; phenolic compounds; acetonic extracts; nutraceuticals
Subjects:Sciences > Chemistry > Molecular biology
Medical sciences > Pharmacy
Medical sciences > Pharmacy > Pharmaceutical chemistry
ID Code:73902
Deposited On:20 Jul 2022 14:31
Last Modified:03 Aug 2022 07:45

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