Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review



Downloads per month over past year

Pozo de la Calle, Susana del and Gómez Martínez, Sonia and Díaz, Ligia E. and Nova Rebato, Esther and Urrialde de Andrés, Rafael and Marcos, Ascensión (2022) Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review. Nutrients, 14 (8). p. 1682. ISSN 2072-6643

[thumbnail of nutrients-14-01682-v2.pdf]
Creative Commons Attribution.


Official URL: https://doi.org/10.3390/nu14081682


Artificial sweeteners are additives widely used in our diet. Although there is no consensus, current evidence indicates that sucralose and saccharin could influence the gut microbiota. The aim of this study was to analyze the existing scientific evidence on the effects of saccharin and sucralose consumption on gut microbiota in humans. Different databases were used with the following search terms: sweeteners, non-caloric-sweeteners, sucralose, splenda, saccharin, sugartwin, sweet’n low, microbiota, gut microbiota, humans, animal model, mice, rats, and/or in vitro studies. In vitro and animal model studies indicate a dose-dependent relationship between the intake of both sweeteners and gut microbiota affecting both diversity and composition. In humans, long-term study suggests the existence of a positive correlation between sweetener consumption and some bacterial groups; however, most short-term interventions with saccharin and sucralose, in amounts below the ADI, found no significant effect on those groups, but there seems to be a different basal microbiota-dependent response of metabolic markers. Although studies in vitro and in animal models seem to relate saccharin and sucralose consumption to changes in the gut microbiota, more long-term studies are needed in humans considering the basal microbiota of participants and their dietary and lifestyle habits in all population groups. Toxicological and basal gut microbiota effects must be included as relevant factors to evaluate food safety and nutritional consequences of non-calorie sweeteners. In humans, doses, duration of interventions, and number of subjects included in the studies are key factors to interpret the results.

Item Type:Article
Uncontrolled Keywords:saccharin; sucralose; gut microbiota; acceptable daily intake; short-term studies; long-term studies; short-chain fatty acids
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Nursing > Nutrition
ID Code:73908
Deposited On:20 Jul 2022 13:52
Last Modified:03 Aug 2022 07:41

Origin of downloads

Repository Staff Only: item control page