Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

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Pérez González, Fabián and Abusamak, Mohammad and Sáez Alcaide, Luis Miguel and Torres García-Denche, Jesús and Marino, Faleh Ahmad Tamimi (2022) Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial. Oral and Maxillofacial Surgery . ISSN 1865-1569

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Official URL: https://doi.org/10.1007/s10006-022-01104-8



Abstract

Purpose: To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model.
Methods: Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively.
Results: Postoperative swelling and pain perception did not show signifcative diference between the control and experimental groups at 24, 48, and 72 h. Trismus was signifcantly lower in the control group than in the experimental group at 72 h postoperatively (p=0.008). Rescue medication consumption seemed to be comparable between groups.
Conclusion: Eliminating night time ibuprofen might be insignifcant for pain control after third molar extraction.


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:Posology, Chronotherapy, Ibuprofen, Extraction, Third molar
Subjects:Medical sciences > Dentistry
Medical sciences > Dentistry > Mouth surgery
ID Code:74114
Deposited On:09 Aug 2022 07:44
Last Modified:09 Aug 2022 07:45

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