Publication: Papel de los factores osteogénicos en el desarrollo de la rigidez arterial asociado a la enfermedad renal
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2022-08-11
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Universidad Complutense de Madrid
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Abstract
La enfermedad renal crónica (ERC) es una patología progresiva con una elevada morbimortalidad y que pronto se convertirá en la quinta causa de muerte a nivel mundial. Esto se debe, entre otras causas, a la falta de marcadores de diagnóstico precoz que permitan la identificación y evaluación de la disfunción renal incipiente, así como la intervención clínica temprana. Por ello, el diagnóstico de la ERC se produce demasiado tarde, cuando ya existe un daño renal establecido que es difícil de revertir. Ello provoca una importante mortalidad cardiovascular (CV), problema que se agrava en los pacientes diabéticos. Una complicación vascular importante y a menudo olvidada de la ERC es el aumento de la rigidez arterial, que conduce a diversas complicaciones CV. Las proteínas morfogenéticas óseas (BMP) son factores decrecimiento pertenecientes a la superfamilia TGF-β que intervienen en una gran variedad de procesos, incluida la formación de hueso...
Chronic kidney disease (CKD) is a progressive pathology with a high morbimortality and will soon become the fifth leading cause of death worldwide. This is due, among other causes, to the lack of early diagnostic markers that allow the identification and evaluation of incipient renal dysfunction, as well as early clinical intervention. As a result, the diagnosis of CKD occurs too late, when there is already an established renal damage that is difficult to reverse. This leads to significant cardiovascular (CV) mortality, a problem that is aggravated in diabetic patients. An important and often overlooked vascular complication of CKD is increased arterial stiffness, leading to various CV complications. Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF-β superfamily that are involved in a wide variety of processes, including bone formation...
Chronic kidney disease (CKD) is a progressive pathology with a high morbimortality and will soon become the fifth leading cause of death worldwide. This is due, among other causes, to the lack of early diagnostic markers that allow the identification and evaluation of incipient renal dysfunction, as well as early clinical intervention. As a result, the diagnosis of CKD occurs too late, when there is already an established renal damage that is difficult to reverse. This leads to significant cardiovascular (CV) mortality, a problem that is aggravated in diabetic patients. An important and often overlooked vascular complication of CKD is increased arterial stiffness, leading to various CV complications. Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF-β superfamily that are involved in a wide variety of processes, including bone formation...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 21-06-2022