Embolization therapy with microspheres for the treatment of liver cancer: State-of-the-art of clinical translation

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Pérez López, Alexandre and Martín Sabroso, Cristina and Gómez Lázaro, Laura and Torres Suárez, Ana Isabel and Aparicio Blanco, Juan (2022) Embolization therapy with microspheres for the treatment of liver cancer: State-of-the-art of clinical translation. Acta Biomaterialia, 149 . pp. 1-15. ISSN 1742-7061

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Official URL: https://doi.org/10.1016/j.actbio.2022.07.019



Abstract

Embolization with microspheres is a therapeutic strategy based on the selective occlusion of the blood vessels feeding a tumor. This procedure is intraarterially performed in the clinical setting for the treatment of liver cancer. The practice has evolved over the last decade through the incorporation of drug loading ability, biodegradability and imageability with the subsequent added functionality for the physicians and improved clinical outcomes for the patients.
This review highlights the evolution of the embolization systems developed through the analysis of the marketed embolic microspheres for the treatment of malignant hepatocellular carcinoma, namely the most predominant form of liver cancer. Embolic microspheres for the distinct modalities of embolization (i.e., bland embolization, chemoembolization and radioembolization) are here comprehensively compiled with emphasis on material characteristics and their impact on microsphere performance. Moreover, the future application of the embolics under clinical investigation is discussed along with the scientific and regulatory challenges ahead in the field.


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:Hepatocellular carcinoma, Chemoembolization, Radioembolization, Intraarterial delivery, Medical devices
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Medicine > Oncology
ID Code:74163
Deposited On:23 Aug 2022 07:44
Last Modified:23 Aug 2022 07:51

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