Force-extension curves for biomolecules



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Carpio, Ana and Bonilla, Luis and Prados, Antonio (2013) Force-extension curves for biomolecules. In 2013 SIAM Conference on Mathematical Aspects of Materials Science, June 9-12, Philadelphia.

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Single-molecule atomic force spectroscopy probes elastic properties of proteins such as titin and ubiquitin. We analyze bioprotein folding dynamics under both force and length-clamp conditions by modeling polyprotein modules as particles in a bistable potential, connected by harmonic springs. The study of multistable equilibria in these models explains recorded sawtooth force-extension curves. We show that bifurcations and transitions through quasi-stationary domain configurations modified by thermal noise are involved in observed stepwise and abrupt refolding and unfolding phenomena under force-clamp conditions. These predictions agree with experimental observations.

Item Type:Conference or Workshop Item (Lecture)
Subjects:Sciences > Physics > Physics-Mathematical models
Medical sciences > Biology > Biomathematics
ID Code:74487
Deposited On:04 Oct 2022 08:50
Last Modified:04 Oct 2022 12:55

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