Class II HLA in Georgia Caucasus Tbilisi Georgians and their Mediterranean ancestry: The Usko Mediterranean languages

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Suarez Trujillo, Fabio and Rey, Diego and Bendukidze, Nina and Juarez, Ignacio and Sánchez Orta, Alejandro and Palaci Gruber, José and Martín Villa, Jose Manuel and Arnaiz Villena, Antonio (2022) Class II HLA in Georgia Caucasus Tbilisi Georgians and their Mediterranean ancestry: The Usko Mediterranean languages. Human Immunology . ISSN 0198-8859

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Official URL: https://doi.org/10.1016/j.humimm.2022.08.005



Abstract

Georgia (or Sakartvelo in its own language) is a South Caucasus Mts. country with its easternmost part is enigmatically named Iberia, like the Iberian Peninsula, which may refer to rivers “Kura” and “Ebro” or their valleys respectively. Most of their inhabitants speak Georgian which is included within Dene-Caucasian group and Usko-Mediterranean subgroup of languages. The latter includes Basque, Berber, ancient Iberian-Tartessian, Etruscan, Hittite, Minoan Lineal A and others. In the present paper, HLA class II -DRB1 and -DQB1 alleles has been studied and extended haplotypes calculated. Most frequent haplotypes are also of Mediterranean origin (i. e.: (A*02-B*51)-DRB1*11:01-DQB1*03:01, (A*02-B*51)-DRB1*13:01-DQB1*06:03, or (A*24-B*35)-DRB1*01:01-DQB1*05:01) and DA genetic distances show that closest world populations to Georgians are Mediterraneans. Georgians also show common extended haplotypes ((A*02-B*51)-DRB1*11:01-DQB1*03:01, (A*02-B*13)-DRB1*07:01-DQB1*02:01 and (A*03-B*35)-DRB1*11:01-DQB1*03:01) with Svan people, a secluded population in North Georgia mountains. We can conclude that Georgians belong to a very old Mediterranean substratum according to both linguistics (Usko Mediterranean languages) and HLA genetics.


Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:HLA, Georgia, Usko‐Mediterranean, Dene‐Caucasian, Caucasus, Svan, Iberian, Tartessian, Etruscan, Basque, Berber, Iberia, Kartli, Sakartvelo, Tbilisi, Kura, Ebro
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Medicine > Medicine history
Humanities > History
ID Code:74604
Deposited On:19 Sep 2022 11:39
Last Modified:18 Oct 2022 08:52

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