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Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer



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Corchado Cobos, Roberto and García Sancha, Natalia and Mendiburu Eliçabe, Marina and Gómez Vecino, Aurora and Jiménez Navas, Alejandro and Pérez Baena, Manuel Jesús and Holgado Madruga, Marina and Mao, Jian Hua and Cañueto, Javier and Castillo Lluva, Sonia and Pérez Losada, Jesús (2022) Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer. Cancers, 14 (2). p. 322. ISSN 2072-6694

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Official URL: https://doi.org/10.3390/cancers14020322


Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of these metabolic changes are located in the tumor parenchymal cells, where oncogenic mutations induce an imperative need to proliferate and cause tumor initiation and progression. Cancer cells undergo significant metabolic reorganization during disease progression that is tailored to their energy demands and fluctuating environmental conditions. Oxidative stress plays an essential role as a trigger under such conditions. These metabolic changes are the consequence of the interaction between tumor cells and stromal myofibroblasts. The metabolic changes in tumor cells include protein anabolism and the synthesis of cell membranes and nucleic acids, which all facilitate cell proliferation. They are linked to catabolism and autophagy in stromal myofibroblasts, causing the release of nutrients for the cells of the tumor parenchyma. Metabolic changes lead to an interstitium deficient in nutrients, such as glucose and amino acids, and acidification by lactic acid. Together with hypoxia, they produce functional changes in other cells of the tumor stroma, such as many immune subpopulations and endothelial cells, which lead to tumor growth. Thus, immune cells favor tissue growth through changes in immunosuppression. This review considers some of the metabolic changes described in breast cancer.

Item Type:Article
Uncontrolled Keywords:metabolism; interstitium; glucose; lactate; hypoxia; cancer-associated fibroblasts; macrophages
Subjects:Medical sciences > Medicine > Oncology
Medical sciences > Psychology
ID Code:74830
Deposited On:06 Oct 2022 12:03
Last Modified:07 Oct 2022 08:12

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