Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions



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Arcos Navarrete, Daniel and Gomez Cerezo, Natividad and Saiz-Pardo Sanz, Melchor and Pablo Velasco, David de and Ortega Medina, Luis and Enciso, Silvia and Fernández Tomé, Blanca and Díaz Güemes, Idoia and Sánchez Margallo, Francisco Miguel and Casarrubios Palomar, Luis and Feito Castellano, María José and Portolés Pérez, María Teresa and Vallet Regí, María (2022) Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions. Acta Biomaterialia, 151 . pp. 501-511. ISSN 1742-7061

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The osteogenic capability of mesoporous bioactive nanoparticles (MBNPs) in the SiO2–CaO system has been assessed in vivo using an osteoporotic rabbit model. MBNPs have been prepared using a double template method, resulting in spherical nanoparticles with a porous core-shell structure that has a high surface area and the ability to incorporate the anti-osteoporotic drug ipriflavone. In vitro expression of the pro-inflammatory genes NF-κB1, IL-6, TNF-α, P38 and NOS2 in RAW-264.7 macrophages, indicates that these nanoparticles do not show adverse inflammatory effects. An injectable system has been prepared by suspending MBNPs in a hyaluronic acid-based hydrogel, which has been injected intraosseously into cavitary bone defects in osteoporotic rabbits. The histological analyses evidenced that MBNPs promote bone regeneration with a moderate inflammatory response. The incorporation of ipriflavone into these nanoparticles resulted in a higher presence of osteoblasts and enhanced angiogenesis at the defect site, but without showing significant differences in terms of new bone formation.

Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID U-1678-2017 (María Teresa Portolés Pérez)
ORCID 0000-0002-9681-0184 (María Teresa Portolés Pérez)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous bioactive nanoparticles, Osteoporosis, Bone regeneration, Ipriflavone, Hyaluronic acid
Subjects:Medical sciences > Medicine > Musculoskeletal System
Medical sciences > Pharmacy > Biochemistry
Medical sciences > Pharmacy > Pharmaceutical chemistry
ID Code:74872
Deposited On:30 Sep 2022 10:38
Last Modified:16 Nov 2022 11:08

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