Selective Serotonin Reuptake Inhibitors as a risk factor for dental implant fail- ure: A retrospective clinical study



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Rodríguez Pena, Karen and Salgado Peralvo, Angel Orión and Kewalramani, Naresh and Suárez Quintanilla, Juan Antonio and Suárez Quintanilla, José María (2022) Selective Serotonin Reuptake Inhibitors as a risk factor for dental implant fail- ure: A retrospective clinical study. British Journal of Oral and Maxillofacial Surgery . ISSN 1532-1940

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Introduction: The trend in recent decades in Europe and the United States points to an exponential increase in the consumption of antidepressant drugs and, in particular, selective serotonin reuptake inhibitors (SSRIs). This retrospective study aims to investigate whether there is an association between SSRI intake and dental implant (DI) failure and, secondarily, the influence of other systemic and local factors.
Material and Methods: This cohort retrospective study is in concordance with the STROBE guidelines for observational studies. One-hundred seventy patients received 573 DIs between 2014 and 2020.
Results: The reported DI failure rate was 6.11%. Of these, 18.31% failed in patients treated with SSRIs while 4.38% failed in healthy patients (p<0.001). Specifically, the use of these drugs was associated with a 4.53 times higher rate of DI failure, and, in the multivariate analysis, 3.70 times higher adjusted risk was found. A lower survival rate at 90 months follow-up was also observed in these patients compared to those not taking these drugs (84.30% vs. 96%; p=0.00014).
Conclusions: With the limitations of the present study, it can be affirmed that there is a relationship between the intake of SSRIs and DI failure, as well as a lower survival rate in these patients.

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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:dental implant failure; dental implant complications; dental implants; selective serotonin reuptake inhibitors; SSRI; antidepressant.
Subjects:Medical sciences > Dentistry > Dental implants
Medical sciences > Dentistry > Mouth surgery
ID Code:74886
Deposited On:03 Oct 2022 09:54
Last Modified:20 Dec 2022 16:25

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