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Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis



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Fernández Agra, María and González Serrano, José and Pedro Herráez, Miguel de and Virto Ruiz, Leire and Caponio, Vito Carlo Alberto and Ibáñez Prieto, Elena and Hernández Vallejo, Gonzalo and López-Pintor Muñoz, Rosa María (2022) Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis. Oral Diseases . ISSN 1601-0825

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Official URL: https://doi.org/10.1111/odi.14390


The objective of this systematic review was to evaluate which salivary biomarkers are altered in patients with burning mouth syndrome (BMS) compared to a control group (CG). A comprehensive literature search was conducted in four databases. Case– control studies evaluating salivary biomarkers in BMS patients were included. Risk of bias was assessed using the Newcastle-Ottawa tool. RevMan was used for metaanalysis. Seventeen studies were selected. The included studies collected 54 different biomarkers. Of these biomarkers, only three (cortisol, α-amylase, and dehydroepiandrosterone) were analyzed in three or more studies. Dehydroepiandrosterone obtained contradictory results among the studies. However, cortisol and α-amylase levels were found to be higher in BMS patients. Cortisol was the only biomarker which could be included for meta-analysis. Cortisol levels were significantly higher in the BMS group compared to the CG (Mean Difference = 0.39; 95% CI [0.14–0.65]; p = 0.003). In conclusion, different studies investigated salivary biomarkers in patients with BMS compared to a CG, with controversial results. Meta-analysis, confirmed by trial-sequential analysis, showed how cortisol levels were significantly higher in BMS. Cortisol emerges as an interesting salivary biomarker in BMS, but future properly designed studies are needed to evaluate its role in diagnosis and/or response to treatment.

Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:biomarkers, burning mouth syndrome, saliva, salivary biomarkers
Subjects:Medical sciences > Dentistry
ID Code:74939
Deposited On:05 Oct 2022 08:38
Last Modified:05 Oct 2022 08:42

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