The ESCRT machinery: remodeling, repairing, and sealing membranes

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Olmos Buchelt, Yolanda (2022) The ESCRT machinery: remodeling, repairing, and sealing membranes. Membranes, 12 (6). pp. 1-16. ISSN Electronic: 2077-0375

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Official URL: https://doi.org/10.3390/membranes12060633




Abstract

The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III, together with the AAA ATPase VPS4, harbors the main remodeling and scission function of the ESCRT machinery, whereas earlyacting ESCRTs mainly contribute to protein sorting and ESCRT-III recruitment through association with upstream targeting factors. Here, we review recent advances in our understanding of the molecular mechanisms that underlie membrane constriction and scission by ESCRT-III and describe the involvement of this machinery in the sealing and repairing of damaged cellular membranes, a key function to preserve cellular viability and organellar function.


Item Type:Article
Uncontrolled Keywords:ESCRT; Membrane scission; Reverse topology; Nuclear envelope; Lysosome; Membrane sealing; Membrane repair
Subjects:Medical sciences > Biology > Cytology
Medical sciences > Biology > Molecular biology
ID Code:75043
Deposited On:11 Oct 2022 11:45
Last Modified:13 Oct 2022 07:46

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