Publication: Investigación del potencial neuroprotector de los cannabinoides en un modelo murino de ataxia espinocerebelosa tipo 3
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2022-10-11
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Universidad Complutense de Madrid
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Abstract
La ataxia espinocerebelosa tipo 3 (SCA-3) es una enfermedad neurodegenerativa de origen genético. Esta enfermedad es causada por un aumento patológico en el número de repeticiones del triplete CAG en el gen que codifica la ataxina-3. El síntoma más característico de esta enfermedad es la aparición de ataxia progresiva, que suele ir acompañada de un amplio abanico de síntomas entre los que se incluyen alteraciones en algunas funciones cognitivas. Como en muchas otras enfermedades neurodegenerativas, hasta la fecha no se ha desarrollado ningún tratamiento efectivo para la SCA-3, por lo que se hace necesario buscar posibles dianas terapéuticas.El sistema endocannabinoide (SEC) es un sistema neuromodulador cuya activación puede desencadenar una serie de respuestas neuroprotectoras. Se ha visto que en la SCA-3, al igual que ocurre en otras enfermedades neurodegenerativas, algunos de los elementos clásicos del SEC, como los receptores CB1 y CB2, y las enzimas de degradación FAAH y MAGL están desregulados. Por ello, el SEC se posiciona como una prometedora opción terapéutica para esta patología...
Spinocerebellar ataxia type 3 (SCA-3) is a neurodegenerative disease of genetic origin. This disease is caused by a pathological increase in the number of CAG triplet repeats in the gene encoding ataxin-3. The most characteristic symptom of this disease is the onset of progressive ataxia, which is usually accompanied by a wide range of symptoms including alterations in some cognitive functions. As in many other neurodegenerative diseases, no effective treatment for SCA-3 has been developed to date, making it necessary to search for possible therapeutic targets.The endocannabinoid system (ECS) is a neuromodulatory system whose activation can trigger several neuroprotective responses. It has been shown that in SCA-3, as in other neurodegenerative diseases, some of the classical elements of the ECS, like the CB1 and CB2 receptors, as well as the degradation enzymes FAAH and MAGL, are deregulated. Therefore, ECS is positioned as a promising therapeutic option for this pathology...
Spinocerebellar ataxia type 3 (SCA-3) is a neurodegenerative disease of genetic origin. This disease is caused by a pathological increase in the number of CAG triplet repeats in the gene encoding ataxin-3. The most characteristic symptom of this disease is the onset of progressive ataxia, which is usually accompanied by a wide range of symptoms including alterations in some cognitive functions. As in many other neurodegenerative diseases, no effective treatment for SCA-3 has been developed to date, making it necessary to search for possible therapeutic targets.The endocannabinoid system (ECS) is a neuromodulatory system whose activation can trigger several neuroprotective responses. It has been shown that in SCA-3, as in other neurodegenerative diseases, some of the classical elements of the ECS, like the CB1 and CB2 receptors, as well as the degradation enzymes FAAH and MAGL, are deregulated. Therefore, ECS is positioned as a promising therapeutic option for this pathology...
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esis inédita de la Universidad Complutense de Madrid, Facultad de Psicología, leída el 27-04-2022