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Control of Gene Expression via the Yeast CWI Pathway



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Sanz Santamaría, Ana Belén and García Sánchez, Raúl and Pavón Vergés, Mónica and Rodríguez Peña, José Manuel and Arroyo, Javier (2022) Control of Gene Expression via the Yeast CWI Pathway. International Journal of Molecular Sciences, 23 (3). p. 1791. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms23031791


Living cells exposed to stressful environmental situations can elicit cellular responses that guarantee maximal cell survival. Most of these responses are mediated by mitogen-activated protein kinase (MAPK) cascades, which are highly conserved from yeast to humans. Cell wall damage conditions in the yeast Saccharomyces cerevisiae elicit rescue mechanisms mainly associated with reprogramming specific transcriptional responses via the cell wall integrity (CWI) pathway. Regulation of gene expression by this pathway is coordinated by the MAPK Slt2/Mpk1, mainly via Rlm1 and, to a lesser extent, through SBF (Swi4/Swi6) transcription factors. In this review, we summarize the molecular mechanisms controlling gene expression upon cell wall stress and the role of chromatin structure in these processes. Some of these mechanisms are also discussed in the context of other stresses governed by different yeast MAPK pathways. Slt2 regulates both transcriptional initiation and elongation by interacting with chromatin at the promoter and coding regions of CWI-responsive genes but using different mechanisms for Rlm1- and SBF-dependent genes. Since MAPK pathways are very well conserved in eukaryotic cells and are essential for controlling cellular physiology, improving our knowledge regarding how they regulate gene expression could impact the future identification of novel targets for therapeutic intervention.

Item Type:Article
Uncontrolled Keywords:transcriptional activation; stress adaptive response; MAPK; gene expression; chromatin; CWI pathway
Subjects:Medical sciences > Biology > Genetics
ID Code:75101
Deposited On:21 Oct 2022 10:18
Last Modified:21 Oct 2022 11:00

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