Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV



Downloads per month over past year

Manzano, Mónica and Talavera Rodríguez, Alba and Moreno, Elena and Madrid, Nadia and Gosalbes, María José and Ron, Raquel and Dronda, Fernando and Pérez Molina, José A. and Lanza, Val F. and Díaz, Jorge and Moreno, Santiago and Navia, Beatriz and Serrano Villar, Sergio (2022) Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV. Nutrients, 14 (6). p. 1221. ISSN 2072-6643

[thumbnail of nutrients-14-01221-v2.pdf]
Creative Commons Attribution.


Official URL:


While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.

Item Type:Article
Uncontrolled Keywords:HIV; diet; microbiota; Lachnospira; Erysipelotrichaceae; inflammatory biomarkers; D-dimer; TNF
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Nursing > Nutrition
ID Code:75125
Deposited On:28 Oct 2022 11:01
Last Modified:04 Nov 2022 12:45

Origin of downloads

Repository Staff Only: item control page