Publication: Criterios histológicos y moleculares del cáncer prostático organoconfinado como factores pronósticos de recidiva
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2022-10-17
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Universidad Complutense de Madrid
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Abstract
En el conjunto de la población española, el cáncer de próstata (CP) es el tumor más frecuente solo por detrás del cáncer colorrectal, y constituye la neoplasia más frecuente entre varones en la UE con excepción del cáncer cutáneo no melanoma, según los datos del European Cancer Information System en 2020.En el CP, existen parámetros histológicos clásicos con valor pronóstico demostrado en la pieza de resección prostática (PR). Uno de los descritos es el carcinoma intraductal (CID), presente aproxi-madamente en el 17 % de las piezas de prostatectomía radical (PR), y con valor pronóstico inde-pendiente reconocido, según la Organización Mundial de la Salud.La complejidad y heterogeneidad del CP han motivado la búsqueda de biomarcadores prácticos y objetivos, que aporten información clínicamente relevante sobre las características biológicas y la evolución previsible de la enfermedad. Algunos de los marcadores moleculares propuestos han mostrado buenos valores predictivos, pero en muchos casos no están validados o no han alcanzado el suficiente nivel de aceptación como para ser incorporados a la práctica clínica. El objeto de estudio de esta Tesis es la valoración pronóstica de biomarcadores en la recidiva bio-química (RBQ) del CP, así como de parámetros histológicos predictivos con especial referencia al CID...
Prostatic cancer (PC) is the most frequent tumor in the whole Spanish population only preceded by colorectal cancer. It is also the most frequent neoplasia in men in the EU, with the exception of the nonmelanoma skin cancer (European Cancer Information System, 2020).There are standard histological parameters in the PC, that have a well demonstrated prognostic value in the radical prostatectomy specimen. Intraductal carcinoma (IDC) which is present in prox-imately 17 % of the radical prostatectomy specimens, has been recently described by the World Health Organization, as one with independent prognostic value.The complexity and heterogeneity of the PC have promoted the search for practical and objective biomarkers, which may be able to give clinically relevant information about biological features and expected evolution of the disease. Some of the proposed molecular markers have good predictive values, but in many cases they have not been validated either have not reached sufficient level of acceptance as needed for being adopted in the daily practice.The presence of predictive histological parameters, specially IDC, and the prognostic evaluation of six biomarkers with respect to biochemical recurrence (BQR), are matter of study in the present Thesis...
Prostatic cancer (PC) is the most frequent tumor in the whole Spanish population only preceded by colorectal cancer. It is also the most frequent neoplasia in men in the EU, with the exception of the nonmelanoma skin cancer (European Cancer Information System, 2020).There are standard histological parameters in the PC, that have a well demonstrated prognostic value in the radical prostatectomy specimen. Intraductal carcinoma (IDC) which is present in prox-imately 17 % of the radical prostatectomy specimens, has been recently described by the World Health Organization, as one with independent prognostic value.The complexity and heterogeneity of the PC have promoted the search for practical and objective biomarkers, which may be able to give clinically relevant information about biological features and expected evolution of the disease. Some of the proposed molecular markers have good predictive values, but in many cases they have not been validated either have not reached sufficient level of acceptance as needed for being adopted in the daily practice.The presence of predictive histological parameters, specially IDC, and the prognostic evaluation of six biomarkers with respect to biochemical recurrence (BQR), are matter of study in the present Thesis...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 24-03-2022