Social environment as a modulator of immunosenescence



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Garrido Tarrio, Antonio and Martínez de Toda Cabeza, Irene and Díaz del Cerro, Estefanía and Félix, Judith and Ceprián, Noemí and González Sánchez, M. and Fuente del Rey, Mónica de la (2022) Social environment as a modulator of immunosenescence. Expert Reviews in Molecular Medicine . pp. 1-16. ISSN Electronic: 1462-3994

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Immune system aging, a process known as immunosenescence, involves a striking rearrangement affecting all immune cells, resulting in an increased rate of infections and a major incidence of autoimmune diseases and cancer. Nonetheless, differences in how individuals of the same chronological age carry out this immunosenescence establishment and thus the aging rate have been reported. In the context of neuroimmunoendocrine communication and its role in the response to stress situations, growing evidence suggests that social environments profoundly influence all physiological responses, especially those linked to immunity. Accordingly, negative contexts (loneliness in humans/social isolation in rodents) were associated with immune impairments and decreased lifespan. However, positive social environments have been correlated with adequate immunity and increased lifespan. Therefore, the social context in which an individual lives is proposed as a decisive modulator of the immunosenescence process and, consequently, of the rate of aging. In this review, the most important findings regarding how different social environments (negative and positive) modulate immunosenescence and therefore the aging rate, as well as the role of stress responses, hormesis, and resilience in these environments will be explained. Finally, several possible molecular mechanisms underlying the effects of negative and positive environments on immunosenescence will be suggested.

Item Type:Article
Uncontrolled Keywords:Aging; Homeostatic systems; Immunosenescence; Loneliness; social environment; Social strategy; Stress response
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Biology > Animal physiology
ID Code:75191
Deposited On:19 Oct 2022 12:12
Last Modified:19 Oct 2022 15:05

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