Publication: Evaluación Inmunológica de Terapias Inmunomoduladoras con Inmunoglobulinas y con Células mesenquimales en pacientes inmunosuprimidos por trasplante o por SARS-CoV-2
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2022-10-21
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Universidad Complutense de Madrid
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Abstract
PARTE 1 Las infecciones se mantienen como una causa relevante de morbilidad y de un incremento de costos tras un trasplante de órgano sólido (TOS). La inmunodeficiencia secundaria de anticuerpos, definida como hipogammaglobulinemia IgG (HGG) se ha vinculado a un riesgo elevado de desarrollar infecciones severas en esta condición clínica. PARTE 2 A la fecha, 15 de noviembre del 2021, se han realizado numerosas investigaciones intensivas y ensayos clínicos, sin embargo, no se ha encontrado un tratamiento eficaz para pacientes con la enfermedad por coronavirus (COVID-19) de grado severo o crítico. Estudios previos han reportado que las células madre mesenquimales de placenta humana (pMSCs) presentan propiedades inmunomoduladoras en otros contextos inflamatorios...
PART 1 Infections remain a significant cause of morbidity and increased costs after a solid organ transplant (SOT). Secondary antibody deficiency defined as IgG hypogammaglobulinemia (HGG), has been linked to an increased risk of developing severe infections in this clinical setting. PART 2 To date, November 15, 2021, several intensive research, and clinical trials have been conducted, however, an efficacious treatment for severe and critical COVID-19 patients is lacking. Previous studies have reported that human placental mesenchymal stem cells (pMSCs) have immunomodulatory properties in other inflammatory contexts...
PART 1 Infections remain a significant cause of morbidity and increased costs after a solid organ transplant (SOT). Secondary antibody deficiency defined as IgG hypogammaglobulinemia (HGG), has been linked to an increased risk of developing severe infections in this clinical setting. PART 2 To date, November 15, 2021, several intensive research, and clinical trials have been conducted, however, an efficacious treatment for severe and critical COVID-19 patients is lacking. Previous studies have reported that human placental mesenchymal stem cells (pMSCs) have immunomodulatory properties in other inflammatory contexts...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 30-03-2022