Publication: Streptococcus pneumoniae y Staphylococcus aureus : enfermedad invasiva, biofilm y terapia
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2022-11-08
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Universidad Complutense de Madrid
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Abstract
Streptococcus pneumoniae (neumococo) es el principal responsable de neumonía bacteriana adquirida en comunidad. Su principal factor de virulencia es el polisacárido capsular (CPS), dividiéndolo en, al menos, 101 serotipos. Entre un 5–10% de adultos y un 20–40% de niños, están colonizados por este patógeno, siendo este estado de portador en la nasofaringe, un prerrequisito para la posterior diseminación a vías estériles y producir enfermedad neumocócica invasiva (ENI). La ENI es prevenible por vacunación, en la actualidad se usan en España dos vacunas: la vacuna conjugada13-valente (VCN13) y la vacuna polisacarídica 23-valente (VPN23). Desde la introducción de las vacunas conjugadas se ha observado un fenómeno denominado reemplazo de serotipos. Staphylococcus aureus, es otro patógeno relevante responsable de un rango amplio de infecciones, desde menos graves como la foliculitis hasta infecciones invasivas graves como la endocarditis. S. aureus posee un gran arsenal de factores de virulencia como el CPS, presente en más del 90% de los aislados clínicos. Su principal relevancia clínica reside en su resistencia a antibióticos, especialmente S. aureus resistente a meticilina (SARM). S. aureus coloniza hasta el 80% de individuos...
Streptococcus pneumoniae (pneumococcus) is the main responsible of bacterial community-acquired pneumonia. Its main virulence factor is the capsular polysaccharide (CPS), which classifies the pneumococcus in at least 101 different serotypes. Between 5-10% of adults and up to 40% of children are colonized asymptomatically,being the carrier state a requirement for the development of invasive pneumococcal disease (IPD). IPD is vaccine-preventable, there are two vaccines used in Spain: the 13-valent pneumococcal conjugate vaccine (PCV13) for children and adults and the 23-valent pneumococcal polysaccharide vaccine (PPV23) for adults. Since the introduction of conjugate vaccines, non-vaccine serotypes have emerged, a phenomenon called serotype replacement. Staphylococcus aureus, also a relevant pathogen, is responsible for a wide range of diseases: from less severe such as folliculitis to severe invasive diseases like endocarditis. S. aureus has an arsenal of virulence factors to evade the immune system including a CPS, present in up to 90% of clinical isolates. The main clinical relevance of S. aureus remains in its great clinical impact due to the antibiotic resistance, specifically caused by methicillin-resistant S. aureus (MRSA) strains. S. aureus colonizes up to 80% of the population...
Streptococcus pneumoniae (pneumococcus) is the main responsible of bacterial community-acquired pneumonia. Its main virulence factor is the capsular polysaccharide (CPS), which classifies the pneumococcus in at least 101 different serotypes. Between 5-10% of adults and up to 40% of children are colonized asymptomatically,being the carrier state a requirement for the development of invasive pneumococcal disease (IPD). IPD is vaccine-preventable, there are two vaccines used in Spain: the 13-valent pneumococcal conjugate vaccine (PCV13) for children and adults and the 23-valent pneumococcal polysaccharide vaccine (PPV23) for adults. Since the introduction of conjugate vaccines, non-vaccine serotypes have emerged, a phenomenon called serotype replacement. Staphylococcus aureus, also a relevant pathogen, is responsible for a wide range of diseases: from less severe such as folliculitis to severe invasive diseases like endocarditis. S. aureus has an arsenal of virulence factors to evade the immune system including a CPS, present in up to 90% of clinical isolates. The main clinical relevance of S. aureus remains in its great clinical impact due to the antibiotic resistance, specifically caused by methicillin-resistant S. aureus (MRSA) strains. S. aureus colonizes up to 80% of the population...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, leída el 29-04-2022