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Validation of the Spanish Acute Cystitis Symptoms Score (ACSS) in native Spanish‐speaking women of Europe and Latin America



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Medina Polo, José and Arrébola Pajares, Ana and Corrales Riveros, Juan Guillermo and Alidjanov, Jakhongir F. and Lorenzo Gómez, María F. and Tapia, Ana María H. and Martínez Berganza, María Lourdes and Ospina Galeano, Irma A. and Padilla Fernández, Bárbara and Pilatz, Adrian and Naber, Kurt G. and Wagenlehner, Florian M. (2022) Validation of the Spanish Acute Cystitis Symptoms Score (ACSS) in native Spanish‐speaking women of Europe and Latin America. Neurourology and Urodynamics . ISSN 0733-2467

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Official URL: https://doi.org/10.1002/nau.25079


Introduction and Objectives: The Acute Cystitis Symptom Score (ACSS) is a patient self-reporting questionnaire for clinical diagnostics and patient-reported outcome (PRO), which may assess the symptoms and the effect on the quality of life in women with acute cystitis (AC). The current study aimed to create a validated Spanish version of the ACSS questionnaire.

Material and Methods: The process of linguistic validation of the Spanish version of the ACSS consisted of the independent forward and backward translations, revision and reconciliation, and cognitive assessment. Clinical evaluation of the study version of the ACSS was carried out in clinics in Spain and Latin America. Statistical tests included the calculation of Cronbach's α, split-half reliability, specificity, sensitivity, diagnostic odds ratio, positive and negative likelihood ratio, and area under the receiver-operating characteristic curve (AUC).

Results: The study was performed on 132 patients [age (mean;SD) 45.0;17.8 years] with AC and 55 controls (44.5;12.2 years). Cronbach's α of the ACSS was 0.86, and the split-half reliability was 0.82. The summary scores of the ACSS domains were significantly higher in patients than in controls, 16.0 and 2.0 (p < 0.001), respectively. The predefined cut-off point of ≥6 for a summary score of the “Typical” domain resulted in a specificity of 83.6% and a sensitivity of 99.2% for the Spanish version of the ACSS. AUC was 0.91 [0.85; 0.97].

Conclusions: The validated Spanish ACSS questionnaire evaluates the symptoms and clinical outcomes of patients with AC. It can be used as a patient's self-diagnosis of AC, as a PRO measure tool, and help to rule out other pathologies in patients with voiding syndrome.

Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:acute cystitis; patient‐reported outcome (PRO), questionnaire, urinary tract infection (UTI); women
Subjects:Medical sciences > Medicine > Nephrology and Urology
ID Code:75437
Deposited On:08 Nov 2022 13:56
Last Modified:14 Nov 2022 11:55

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