Real-time monitoring of breath biomarkers with a magnetoelastic contactless gas sensor: a proof of concept

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Peña Moreno, Álvaro and Aguilera, Juan Diego and Matatagui Cruz, Daniel and Presa Muñoz del Toro, Patricia de la and Horrillo, Carmen and Hernando Grande, Antonio and Marín Palacios, María Pilar (2022) Real-time monitoring of breath biomarkers with a magnetoelastic contactless gas sensor: a proof of concept. Biosensors basel, 12 (10). ISSN 2079-6374

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Official URL: http://dx.doi.org/10.3390/bios12100871




Abstract

In the quest for effective gas sensors for breath analysis, magnetoelastic resonance-based gas sensors (MEGSs) are remarkable candidates. Thanks to their intrinsic contactless operation, they can be used as non-invasive and portable devices. However, traditional monitoring techniques are bound to slow detection, which hinders their application to fast bio-related reactions. Here we present a method for real-time monitoring of the resonance frequency, with a proof of concept for real-time monitoring of gaseous biomarkers based on resonance frequency. This method was validated with a MEGS based on a Metglass 2826 MB microribbon with a polyvinylpyrrolidone (PVP) nanofiber electrospun functionalization. The device provided a low-noise (RMS = 1.7 Hz), fast (<2 min), and highly reproducible response to humidity (Delta f = 46-182 Hz for 17-95% RH), ammonia (Delta f = 112 Hz for 40 ppm), and acetone (Delta f = 44 Hz for 40 ppm). These analytes are highly important in biomedical applications, particularly ammonia and acetone, which are biomarkers related to diseases such as diabetes. Furthermore, the capability of distinguishing between breath and regular air was demonstrated with real breath measurements. The sensor also exhibited strong resistance to benzene, a common gaseous interferent in breath analysis.


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© 2022 by the authors. Licensee MDPI
Author A.P. received funding from grant PRE2019-0875001234, Ministerio de Ciencia e Innovación (MCI), Spain. D.M. received funding from Comfuturo, Consejo Superior de Investigaciones Científicas, Spain. Authors A.P., D.M., P.M. and C.H. received funding from projects RTI2018-095856-B-C21 and RTI2018-095856-B-C22, Ministerio de Ciencia e Innovación, Spain. A.P. and P.M. received funding S2018/NMT-4321, Comunidad de Madrid. J.D.A received funding from Next Generation EU, Ministerio de Trabajo y Economía, Comunidad de Madrid, Spain, Programa Investigo from grant 96-UCM-INV.

Uncontrolled Keywords:Volatile organic-compounds; Wireless; Ammonia; Temperature; Biosensor; Nitrogen; Remote sensing; Gas sensor; Breath analysis; Magnetoelastic resonance; Soft magnets; Polyvinylpyrrolidone; Nanofiber; Humidity; Biomarkers; Diabetes
Subjects:Sciences > Physics > Materials
Sciences > Physics > Solid state physics
ID Code:75586
Deposited On:22 Nov 2022 18:52
Last Modified:23 Nov 2022 12:01

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