Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment.



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Álvarez Corchado, Elena and González Ortiz, Blanca and Lozano Borregón, Daniel and Doadrio Villarejo, Antonio Luis and Colilla, Montserrat and Izquierdo Barba, Isabel (2021) Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment. Pharmaceutics, 13 (12). p. 2033. ISSN 1999-4923

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This review focuses on the design of mesoporous silica nanoparticles for infection treat‐ment. Written within a general context of contributions in the field, this manuscript highlights the major scientific achievements accomplished by Prof. Vallet‐Regí’s research group in the field of silica‐based mesoporous materials for drug delivery. The aim is to bring out her pivotal role on the envisage of a new era of nanoantibiotics by using a deep knowledge on mesoporous materials as drug delivery systems and applying cutting‐edge technologies to design and engineer advanced nanoweapons to fight infection. This review has been divided in two main sections: the first part overviews the influence of the textural and chemical properties of silica‐based mesoporous materials on the loading and release of antibiotic molecules, depending on the host‐guest interactions.Furthermore, this section also remarks the potential of molecular modelling in the design and comprehension of the performance of these release systems. The second part describes the more recent advances in the use of mesoporous silica nanoparticles as versatile nanoplatforms for the development of novel targeted and stimuli‐responsive antimicrobial nanoformulations for future application in personalized infection therapies.

Item Type:Article
Additional Information:

RESEARCHER ID K-4773-2015 (Blanca González Ortiz)
ORCID 0000-0002-0493-6071 (Blanca González Ortiz)
RESEARCH ID B-5081-2017  (Daniel Lozano Borregón)
ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)
RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)
ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)
RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)
ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)

Uncontrolled Keywords:nanoantibiotics; mesoporous silica nanoparticles; targeted therapies; stimuli-response; infection treatment; metal ions
Subjects:Sciences > Chemistry > Materials
ID Code:75589
Deposited On:17 Nov 2022 09:01
Last Modified:29 Nov 2022 10:55

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