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The Factor H protein family: The switchers of the complement alternative pathway

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Lucientes Continente, Laura and Márquez Tirado, Bárbara and Goicoechea de Jorge, Elena (2022) The Factor H protein family: The switchers of the complement alternative pathway. Immunological Reviews . ISSN 0105-2896

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Official URL: https://doi.org/10.1111/imr.13166



Abstract

The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including infectious, inflammatory, autoimmune, and degenerative diseases and cancer. Composed, in man, of seven highly related proteins, FH, factor H-like 1, and 5 factor H-related proteins, some of the FH family proteins are devoted to down-regulating the AP, while others exert an opposite function by promoting AP activation. Recent findings have provided insights into the molecular mechanisms defining their biological roles and their pathogenicity, illustrating the relevance that the balance between the regulators and the activators within this protein family has in defining the outcome of complement activation on cell surfaces. In this review we will discuss the emerging roles of the factor H protein family, their impact in the complement cascade, and their involvement in the pathogenesis of complementmediated diseases associated with the AP dysregulation.


Item Type:Article
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CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:alternative pathway, complement, Factor H, FHL-1, FHRs
Subjects:Medical sciences > Medicine > Immunology
ID Code:75686
Deposited On:21 Nov 2022 11:44
Last Modified:21 Nov 2022 11:47

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