Retinal Disorders in Humans and Experimental ALS Models



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Rojas Lozano, Pilar and Ramírez Sebastián, Ana Isabel and Hoz Montañana, María Rosa de and Cadena Santoyo, Manuel and García Martín, Elena Salobrar and López Cuenca, Inés and Fernández Albarral, José Antonio and Sánchez Puebla, Lídia and Matamoros, José A. and Salazar Corral, Juan José and Ramirez Sebastian, Jose Manuel (2022) Retinal Disorders in Humans and Experimental ALS Models. In Animal Models and Experimental Research in Medicine. IntechOpen, London, 22 p.. (In Press)

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Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that severely impairs the patient’s mobility, as it mainly affects the upper and lower motor neurons in the spinal cord. In addition, alterations have also been demonstrated in different parts of the central nervous system (CNS), such as the brain and brainstem. The retina is a projection to the brain and is considered as a “window” to the CNS. Moreover, it is possible to use the retina as a biomarker in several neurodegenerative diseases, even in the absence of major visual impairment. Classically, it was thought that the eyes were not affected in ALS, with respect to extraocular muscles, whereas the remainder of the muscles of the body were distressed. Nevertheless, retinal changes have recently been found in this pathology and could help in diagnosis, follow-up, and even monitoring therapies in this disease.

Item Type:Book Section
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Submitted: July 25th, 2022 Reviewed: August 10th, 2022 Published: December 13th, 2022

Uncontrolled Keywords:Amyotrophic lateral sclerosis ; ALS ; Retina ; Animal models ; SOD1 ; Microglia ; Protein aggregates ; Axon pathology ; Neurodegeneration ; Neuroinflammation
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
ID Code:75977
Deposited On:15 Dec 2022 17:02
Last Modified:16 Dec 2022 08:13

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