One-Year Changes in Optic Nerve Head Parameters in Recovered COVID-19 Patients



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Burgos Blasco, Bárbara and Güemes Villahoz, Noemi and Vidal Villegas, Beatriz and Martínez de la Casa, Jose Maria and García Feijoo, Julián and Donate López, Juan and Martín Sánchez, Francisco Javier and González Armengol, Juan Jorge and Méndez Hernández, Carmen Dora (2022) One-Year Changes in Optic Nerve Head Parameters in Recovered COVID-19 Patients. Journal of Neuro-ophthalmology, 42 (4). pp. 476-482. ISSN 1070-8022 ; E-ISSN: 1536-5166

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Background: The main purpose was to evaluate the changes in peripapillary retinal nerve fiber layer (RNFL) thickness and vessel density (VD) in post–COVID-19 patients during 12-month follow-up.
Methods: In this prospective study, patients with COVID-19 who were attended in the Hospital Clinico San Carlos (Madrid, Spain) were included. All patients underwent a complete ophthalmological examination, optic nerve head optical coherence tomography (OCT), and OCT angiography (OCTA) using the Cirrus HD-OCT 5,000 with AngioPlex OCTA 1, 3, and 12 months after laboratory-confirmed diagnosis. Sociodemographic data, medical history, disease severity, and laboratory workup were registered.
Results: A total of 180 eyes of 90 patients with SARS-CoV-2 infection were included; the mean age was 55.5 ± 8.9 years, and 46 patients (51%) were females. The mean visual acuity was 0.76 ± 0.16, and no abnormalities attributable to SARS-CoV-2 were detected in the ocular or fundus examination. No differences in the OCT and OCTA data were found between severity groups in each visit (all P > 0.05). Overall, there was a decrease in RNFL global thickness (P < 0.001) from the first to the last visit, and an increase in VD and flux index was noted in some sectors at the 12-month examination. A significant correlation was detected at 12 months between vascularization parameters and RNFL thickness.
Conclusions: One year after SARS-CoV-2 infection, changes in peripapillary RNFL thickness and vascularization occur, possibly indicating a recovery in such parameters.

Item Type:Article
Uncontrolled Keywords:Optic nerve ; Covid-19
Subjects:Medical sciences > Medicine > Communicable diseases
Medical sciences > Medicine > Ophtalmology
ID Code:76000
Deposited On:16 Dec 2022 19:58
Last Modified:19 Dec 2022 07:38

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