¡Nos trasladamos! E-Prints cerrará el 7 de junio.

En las próximas semanas vamos a migrar nuestro repositorio a una nueva plataforma con muchas funcionalidades nuevas. En esta migración las fechas clave del proceso son las siguientes:

Es muy importante que cualquier depósito se realice en E-Prints Complutense antes del 7 de junio. En caso de urgencia para realizar un depósito, se puede comunicar a docta@ucm.es.

Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy



Downloads per month over past year

Fernández Albarral, José Antonio and García Martín, Elena Salobrar and Matamoros, José A. and Fernández Mendivil, Cristina and Sastre, Eric, del and Chen, Leijing and Hoz Montañana, María Rosa de and López Cuenca, Inés and Sánchez Puebla, Lídia and Ramirez Sebastian, Jose Manuel and Salazar Corral, Juan José and García López, Manuela (Manuela G. López) and Ramírez Sebastián, Ana Isabel (2022) Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy. Antioxidants, 11 (11). p. 25. ISSN 2076-3921

[thumbnail of antioxidants-11-02151.pdf]
Creative Commons Attribution.


Official URL: https://doi.org/10.3390/antiox11112151


Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases in microglia, causing iron accumulation, neuroinflammation, and neurodegeneration. The retina is an organ that can be readily accessed and can reflect changes that occur in the brain. In this context, we evaluated how the lack of microglial HO-1, using mice that do not express HO-1 in microglia (HMO-KO), impacts retinal macro and microgliosis of aged subjects (18 months old mice) subjected to tauopathy by intrahippocampal delivery of AAV-hTauP301L (TAU). Our results show that although tauopathy, measured as anti-TAUY9 and anti-AT8 positive immunostaining, was not observed in the retina of WT-TAU or HMO-KO+TAU mice, a morphometric study of retinal microglia and macroglia showed significant retinal changes in the TAU group compared to the WT group, such as: (i) increased number of activated microglia, (ii) retraction of microglial processes, (iii) increased number of CD68+ microglia, and (iv) increased retinal area occupied by GFAP (AROA) and C3 (AROC3). This retinal inflammatory profile was reduced in HMO-KO+TAU mice. Conclusion: Reduction of microglial HO-1 could be beneficial to prevent tauopathy-induced neuroinflammation.

Item Type:Article
Additional Information:

Received: 11 October 2022 / Revised: 27 October 2022 / Accepted: 27 October 2022 / Published: 30 October 2022
This article belongs to the Special Issue Experimental and Therapeutic Targeting of Heme Oxygenase

Uncontrolled Keywords:tauopathies; heme oxygenase 1 (HO-1); retina; microglia; macroglia; neuroinflammation; neurodegenerative diseases
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:76001
Deposited On:16 Dec 2022 19:59
Last Modified:19 Dec 2022 07:38

Origin of downloads

Repository Staff Only: item control page