A new approach to predicting mortality in dialysis patients using sociodemographic features based on artificial intelligence

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Díez Sanmartín, Covadonga and Cabezuelo, Antonio Sarasa and Belmonte, Amado Andrés (2022) A new approach to predicting mortality in dialysis patients using sociodemographic features based on artificial intelligence. Artificial Intelligence in Medicine, 136 . p. 102478. ISSN 09333657

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Official URL: https://doi.org/10.1016/j.artmed.2022.102478




Abstract

One of the main problems that affect patients in dialysis therapy who are on the waiting list to receive a kidney transplant is predicting their survival time if they do not receive a transplant. This paper proposes a new approach to survival prediction based on artificial intelligence techniques combined with statistical methods to study the association between sociodemographic factors and patient survival on the waiting list if they do not receive a kidney transplant. This new approach consists of a first stage that uses the clustering techniques that are best suited to the data structure (K-Means, Mini Batch K-Means, Agglomerative Clustering and K-Modes) used to identify the risk profile of dialysis patients. Later, a new method called False Clustering Discovery Reduction is performed to determine the minimum number of populations to be studied, and whose mortality risk is statistically differentiable. This approach was applied to the OPTN medical dataset (n = 44,663). The procedure started from 11 initial clusters obtained with the Agglomerative technique, and was reduced to eight final risk populations, for which their Kaplan-Meier survival curves were provided. With this result, it is possible to make predictions regarding the survival time of a new patient who enters the waiting list if the sociodemographic profile of the patient is known. To do so, the predictive algorithm XGBoost is used, which allows the cluster to which it belongs to be predicted and the corresponding Kaplan-Meier curve to be associated with it. This prediction process is achieved with an overall Multi-class AUC of 99.08 %.


Item Type:Article
Additional Information:

CRUE-CSIC (Acuerdos Transformativos 2022)

Uncontrolled Keywords:Artificial intelligence; Machine learning; Survival analysis; Dialysis; Kidney transplant; Kidney waiting list
Subjects:Medical sciences > Medicine > Medical telematics
ID Code:76745
Deposited On:21 Feb 2023 12:35
Last Modified:21 Feb 2023 12:35

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