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Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective



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López-Méndez, Tania B. and Sánchez-Álvarez, Miguel and Trionfetti, Flavia and Pedraz, José L. and Tripodi, Marco and Cordani, Marco and Strippoli, Raffaele and González-Valdivieso, Juan (2023) Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective. Cell & Bioscience, 13 (44). pp. 1-17. ISSN 2045-3701

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Official URL: https://doi.org/10.1186/s13578-023-00986-9


In recent years, progress in nanotechnology provided new tools to treat cancer more effectively. Advances in biomaterials tailored for drug delivery have the potential to overcome the limited selectivity and side effects frequently associated with traditional therapeutic agents. While autophagy is pivotal in determining cell fate and adaptation to different challenges, and despite the fact that it is frequently dysregulated in cancer, antitumor therapeutic strategies leveraging on or targeting this process are scarce. This is due to many reasons, including the very contextual effects of autophagy in cancer, low bioavailability and non-targeted delivery of existing autophagy modulatory compounds. Conjugating the versatile characteristics of nanoparticles with autophagy modulators may render these drugs safer and more effective for cancer treatment. Here, we review current standing questions on the biology of autophagy in tumor progression, and precursory studies and the state-of-the-art in harnessing nanomaterials science to enhance the specificity and therapeutic potential of autophagy modulators.

Item Type:Article
Uncontrolled Keywords:Cancer, Nanomedicine, Biomaterials, Clinical trials, Autophagy
Subjects:Medical sciences > Biology > Biotechnology
Medical sciences > Pharmacy > Biochemistry
Medical sciences > Pharmacy > Pharmaceutical chemistry
ID Code:76903
Deposited On:07 Mar 2023 14:57
Last Modified:07 Mar 2023 15:06

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