A Novel Sprouted Oat Fermented Beverage: Evaluation of Safety and Health Benefits for Celiac Individuals



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Aparicio García, Natalia and Martínez Villaluenga, Cristina and Frias, Juana and Crespo Perez, Laura and Fernández, Cristina Fernández and Alba, Claudio and Rodríguez, Juan Miguel and Peñas, Elena (2021) A Novel Sprouted Oat Fermented Beverage: Evaluation of Safety and Health Benefits for Celiac Individuals. Nutrients, 13 (8). p. 2522. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu13082522


The safety and health effects for celiac people of a novel beverage (SOFB) developed from sprouted oat flour by fermentation with Lactobacillus plantarum was explored. In vitro reactivity against anti-gliadin antibodies (AGA) and antioxidant/anti-inflammatory potential of SOFB in RAW 264.7 macrophages and Caco-2 cells were evaluated. Immunoreactivity against AGA and antioxidant activity were not detected in SOFB, but it exhibited significant anti-inflammatory activity. The tolerability and impact of SOFB consumption for 6 months on nutritional status and intestinal microbiota composition were investigated in 10 celiac adults (five treated and five control). SOFB consumption did not adversely affect duodenal mucosa nor the total IgA or anti-tissue transglutaminase antibody (IgA-tTG) levels in celiac participants, but it significantly decreased total cholesterol levels at all sampling times and folic acid levels at the end of the study compared to the placebo beverage. SOFB administration also shifted gut microbiota, leading to a higher relative abundance of some beneficial bacteria including the genera Subdoligranulum, Ruminococcus and Lactobacillus in the SOFB group. This study provides supporting evidence of the safety of health benefits of a novel functional beverage produced from sprouted oat.

Item Type:Article
Uncontrolled Keywords:oat; germination; fermentation; beverage; celiac disease; gluten-free diet; microbiota
Subjects:Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Pharmacy > Dietetics and nutrition
ID Code:77432
Deposited On:20 Apr 2023 12:07
Last Modified:20 Apr 2023 12:07

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