IGF1R as a Potential Pharmacological Target in Allergic Asthma



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Alfaro Arnedo, Elvira and López, Icíar P. and Piñeiro Hermida, Sergio and Ucero Herrería, Álvaro Conrado and Gonzalez Barcala, Francisco Javier and Salgado, Francisco Javier and Pichel, José G. (2021) IGF1R as a Potential Pharmacological Target in Allergic Asthma. Biomedicines, 9 (8). p. 912. ISSN 2227-9059

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Official URL: https://doi.org/10.3390/biomedicines9080912


Background: Asthma is a chronic lung disease characterized by reversible airflow obstruction, airway hyperresponsiveness (AHR), mucus overproduction and inflammation. Although Insulin-like growth factor 1 receptor (IGF1R) was found to be involved in asthma, its pharmacological inhibition has not previously been investigated in this pathology. We aimed to determine if therapeutic targeting of IGF1R ameliorates allergic airway inflammation in a murine model of asthma. Methods: C57BL/6J mice were challenged by house dust mite (HDM) extract or PBS for four weeks and therapeutically treated with the IGF1R tyrosine kinase inhibitor (TKI) NVP-ADW742 (NVP) once allergic phenotype was established. Results: Lungs of HDM-challenged mice exhibited a significant increase in phospho-IGF1R levels, incremented AHR, airway remodeling, eosinophilia and allergic inflammation, as well as altered pulmonary surfactant expression, all of being these parameters counteracted by NVP treatment. HDM-challenged lungs also displayed augmented expression of the IGF1R signaling mediator p-ERK1/2, which was greatly reduced upon treatment with NVP. Conclusions: Our results demonstrate that IGF1R could be considered a potential pharmacological target in murine HDM-induced asthma and a candidate biomarker in allergic asthma.

Item Type:Article
Additional Information:

Correction published on 22 March 2022, see Biomedicines 2022, 10(4), 733.

Uncontrolled Keywords:Asthma; Allergy; House dust mite; IGF1R; NVP-ADW742; Pharmacological blockade
Subjects:Medical sciences > Medicine
Medical sciences > Medicine > Pneumology
ID Code:77705
Deposited On:24 Apr 2023 08:17
Last Modified:24 Apr 2023 09:25

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