Publication: Manifestaciones oftalmológicas asociadas a la enfermedad por Coronavirus (COVID-19)
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2023-04-24
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Universidad Complutense de Madrid
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Abstract
La infección por el coronavirus del síndrome respiratorio agudo severo 2 (SARS-CoV-2), responsable de la enfermedad por coronavirus 2019 (COVID-19), puede afectar a prácticamente todos los órganos, incluidos los ojos. Se ha detectado la presencia ARN de SARS-CoV-2 en lágrima y exudado conjuntival. También se han observado manifestaciones oculares tanto en el segmento anterior como en el segmento posterior, pudiendo aparecer tanto durante la fase aguda de la infección como tras la recuperación de la enfermedad. Además de estos cambios clínicos, se han observado cambios subclínicos en el grosor de las capas de la retina detectables mediante tomografía de coherencia óptica (OCT), y alteraciones en la circulación retiniana cuantificables mediante angiografía por OCT (OCTA). Objetivos: El objetivo principal de esta Tesis se centra en el estudio de la afectación oftalmológica de la COVID-19. Para ello, se ha estudiado la presencia de ARN de SARS-CoV-2 en lágrima y exudado conjuntival, las características clínicas y la frecuencia de la conjuntivitis, y la afectación del segmento posterior mediante exploración del fondo de ojo, OCT y OCTA en pacientes COVID-19...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for coronavirus disease 2019 (COVID-19), may affect virtually all organs, including the eyes. SARS-CoV-2 RNA has been detected in tears and conjunctival swab. Ocular manifestations have also been observed in both the anterior and posterior segments and can appear both during the acute phase of infection and after recovery from the disease. In addition to these clinical changes, subclinical changes in the thickness of retinal layers detected by optical coherence tomography (OCT), and disturbances in retinal circulation measurable by OCT angiography (OCTA) have been observed. Objectives: The main objective of this Thesis focuses on the study of the ophthalmologic involvement of COVID-19. For this purpose, the presence of SARS-CoV-2 RNA in tear and conjunctival exudate, clinical features and frequency of conjunctivitis, and posterior segment involvement by fundus examination, OCT and OCTA in COVID-19 patients have been studied...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for coronavirus disease 2019 (COVID-19), may affect virtually all organs, including the eyes. SARS-CoV-2 RNA has been detected in tears and conjunctival swab. Ocular manifestations have also been observed in both the anterior and posterior segments and can appear both during the acute phase of infection and after recovery from the disease. In addition to these clinical changes, subclinical changes in the thickness of retinal layers detected by optical coherence tomography (OCT), and disturbances in retinal circulation measurable by OCT angiography (OCTA) have been observed. Objectives: The main objective of this Thesis focuses on the study of the ophthalmologic involvement of COVID-19. For this purpose, the presence of SARS-CoV-2 RNA in tear and conjunctival exudate, clinical features and frequency of conjunctivitis, and posterior segment involvement by fundus examination, OCT and OCTA in COVID-19 patients have been studied...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 07-10-2022