Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study



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Aracil Moreno, Irene and Rodríguez Benitez, Patrocinio and Ruiz Minaya, Maria and Bernal Claverol, Mireia and Ortega Abad, Virginia and Hernández Martin, Concepción and Pintado Recarte, Pilar and Yllana, Fátima and Oliver Barrecheguren, Cristina and Álvarez Mon, Melchor and Ortega, Miguel A. and De León Luis, Juan Antonio (2021) Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study. International Journal of Environmental Research and Public Health, 18 (22). p. 11783. ISSN 1660-4601

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Preeclampsia is one of the most worrisome complications during pregnancy, affecting approximately 1 out of 20 women worldwide. Preeclampsia is mainly characterized by a sustained hypertension, proteinuria, also involving a significant organ dysfunction. Moreover, 25% of the cases could be classified as severe preeclampsia (SP), a serious condition that could be life-threatening for both the mother and fetus. Although there are many studies focusing on preeclampsia, less efforts have been made in SP, frequently limited to some specific situations. Thus, the present study aims to conduct a comparative analysis of risk factors, maternal characteristics, obstetric and neonatal outcomes and maternal complications in patients with severe preeclampsia versus patients without severe preeclampsia. Hence, 235 cases and 470 controls were evaluated and followed in our study. We described a set of variables related to the development of severe preeclampsia, including maternal age > 35 years (69.8%), gestational (26.8%) or chronic arterial hypertension (18.3%), obesity (22.6%), use of assisted reproduction techniques (12.3%), prior history of preeclampsia (10.2%) and chronic kidney disease (7.7%) All patients had severe hypertension (>160 mmHg) and some of them presented with additional complications, such as acute renal failure (51 cases), HELLP syndrome (22 cases), eclampsia (9 cases) and acute cerebrovascular accidents (3 cases). No case of maternal death was recorded, although the SP group had a higher cesarean section rate than the control group (60% vs. 20.9%) (p < 0.001), and there was a notably higher perinatal morbidity and mortality in these patients, who had a prematurity rate of 58.3% (p < 0.001) and 14 perinatal deaths, compared to 1 in the control group. Overall, our study recognized a series of factors related to the development of SP and related complications, which may be of great aid for improving the clinical management of this condition.

Item Type:Article
Uncontrolled Keywords:Severe preeclampsia; Maternal risk factors; Pregnancy outcome
Subjects:Medical sciences > Medicine
Medical sciences > Medicine > Gynecology and Obstetrics
Medical sciences > Medicine > Public health
ID Code:77754
Deposited On:25 Apr 2023 07:09
Last Modified:25 Apr 2023 07:16

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